SAB4502834
Anti-SOX9 antibody produced in rabbit
affinity isolated antibody
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All Photos(3)
Synonym(s):
SRY sex determining region Y-box 9 protein, SRY-box containing gene 9, Sox-9, transcription factor SOX-9
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 56 kDa
species reactivity
human, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SOX9(6662)
General description
Anti-SOX9 antibody detects endogenous levels of total SOX9 protein.
The SOX9 (SRY (sex determining region Y)-box 9) gene is located on human chromosome 17q24.3. SOX9 codes for a DNA-binding protein that belongs to the class of high-mobility-group box.
Immunogen
The antiserum was produced against synthesized peptide derived from human SOX9.
Immunogen Range: 147-196
Immunogen Range: 147-196
Biochem/physiol Actions
The protein encoded by SOX9 (SRY (sex determining region Y)-box 9) gene is involved in the regulation of developmental processes such as chondrogenesis, gliogenesis, epithelial hair follicle stem cell specification, gonadogenesis, normal development of septum, lung, cardiac valve and pancreas. Abnormal regulation of SOX9 promotes tumorigenesis in different tissues. SOX9 induces the process of metastasis in cancer cells. Overexpression of the gene is observed in prostate, breast, and colorectal cancers.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
Loss of DDRGK1 modulates SOX9 ubiquitination in spondyloepimetaphyseal dysplasia.
Egunsola AT
The Journal of Clinical Investigation, 127(4), 1475-1484 (2017)
Expression and Clinical Significance of SOX9 in Renal Cell Carcinoma, Bladder Cancer and Penile Cancer.
Wan YP
Oncology research and treatment, 40(1-2), 15-20 (2017)
Position effects due to chromosome breakpoints that map approximately 900 Kb upstream and approximately 1.3 Mb downstream of SOX9 in two patients with campomelic dysplasia.
Velagaleti GV
American Journal of Human Genetics, 76(4), 652-662 (2005)
Hyun Mi Kang et al.
Cell reports, 14(4), 861-871 (2016-01-19)
The kidney has a tremendous capacity to regenerate following injury, but factors that govern this response are still largely unknown. We isolated cells from mouse kidneys with high proliferative and multi-lineage differentiation capacity. These cells expressed a high level of
SOX9 is a proliferation and stem cell factor in hepatocellular carcinoma and possess widespread prognostic significance in different cancer types.
Richtig G
PLoS ONE, 12(11), 1-15 (2017)
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