SAB4502745
Anti-SFRP2 antibody produced in rabbit
affinity isolated antibody
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Synonym(s):
FRP-2, Frizzled-related protein 2, SARP-1, Secreted apoptosis-related protein 1, sFRP-2
UNSPSC Code:
12352203
NACRES:
NA.41
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 33 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:5000
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SFRP2(6423)
General description
Anti-SFRP2 Antibody detects endogenous levels of total SFRP2 protein.
The SFRP2 (secreted frizzled related protein 2) gene is mapped to human chromosome 4q31.3. It is found to be expressed in sclerotome.
Immunogen
The antiserum was produced against synthesized peptide derived from human SFRP2.
Immunogen Range: 119-168
Immunogen Range: 119-168
Biochem/physiol Actions
SFRP2 (secreted frizzled related protein 2) promotes phosphorylation and retards the expression of nuclear β-catenin and inhibits the canonical Wnt signaling pathway. SFRP2 is known to enhance osteogenic differentiation in mesenchymal stem cells.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
SFRP2 enhances the osteogenic differentiation of apical papilla stem cells by antagonizing the canonical WNT pathway.
Jin L
Cellular & Molecular Biology Letters, 22:14, 1-14 (2017)
A novel susceptibility locus for Hirschsprung's disease maps to 4q31.3-q32.3.
Brooks AS
Journal of medical Genetics, 43(7), 1-6 (2006)
SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm.
Lee CS
Development, 127(1), 109-118 (2000)
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