SAB4502580
Anti-Retinoic Acid Receptor α antibody produced in rabbit
affinity isolated antibody
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NR1B1, Nuclear receptor subfamily 1 group B member 1, RAR-α, RARA, Retinoic acid receptor α
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 50 kDa
species reactivity
human, mouse, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... RARA(5914)
General description
Anti-Retinoic Acid Receptor α Antibody detects endogenous levels of total Retinoic Acid Receptor α protein.
Retinoic acid receptor α (RARα) is a nuclear receptor for retinoic acid and is expressed in the retina. It belongs to the nuclear steroid/thyroid hormone receptor superfamily. The gene encoding it is localized on human chromosome 17q21.
Immunogen
The antiserum was produced against synthesized peptide derived from human Retinoic Acid Receptor alpha.
Immunogen Range: 46-95
Immunogen Range: 46-95
Biochem/physiol Actions
Retinoic acid receptor α (RARα) is a ligand-dependent transcriptional modulator of genes that has a role in differentiation, cellular development and apoptosis. It has a role in germ-cell development in testis. The protein may be associated with acute promyelocytic leukemia.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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NLS-RARa promotes proliferation and inhibits differentiation in HL-60 cells.
International Journal of Medical Sciences, 11(3), 247-254 (2014)
The retinoic acid receptor alpha (RARA) gene is not associated with myopia, hypermetropia, and ocular biometric measures.
Molecular Vision, 15, 1390-1397 (2009)
Activity of retinoic acid receptor-alpha is directly regulated at its protein kinase A sites in response to follicle-stimulating hormone signaling.
Endocrinology, 151(5), 2361-2372 (2010)
Enhanced expression of retinoic acid receptor alpha (RARA) induces epithelial-to-mesenchymal transition and disruption of mammary acinar structures.
Molecular Oncology, 9(2), 355-364 (2015)
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