SAB4502541
Anti-CD45 antibody produced in rabbit
affinity isolated antibody
Sign Into View Organizational & Contract Pricing
All Photos(2)
Synonym(s):
L-CA, LY-5, Leukocyte common antigen precursor, Leukocyte common antigen variant 4 precursor, Lymphocyte common antigen Ly-5
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 147 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PTPRC(5788)
General description
Anti-CD45 antibody detects endogenous levels of total CD45 protein.
The CD45 (cluster of differentiation 45) gene is mapped to human chromosome 1q31.3-q32.1. It codes for a type I transmembrane protein and is expressed in nucleated hematopoietic cells along within its precursors. The protein consists of a varying extracellular domain and a highly conserved intracellular domain.
Immunogen
The antiserum was produced against synthesized peptide derived from human CD45.
Immunogen Range: 981-1030
Immunogen Range: 981-1030
Application
Anti-CD45 antibody produced in rabbit has been used in:
- immunohistochemistry staining
- immunofluorescence staining
- immunostaining
Biochem/physiol Actions
The Cluster of differentiation 45 (CD45) facilitates the regulation of lymphocyte signaling and SRC family kinase Lck. This protein participates in the polymorphism in several mammalian species.
The protein encoded by CD45 (cluster of differentiation 45) is a prototypic receptor and exhibits phosphatase activity. CD45 is found to control T-cell mediated BCR-signaling.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Sathish Babu Vasamsetti et al.
Immunity, 49(1), 93-106 (2018-07-01)
There is a growing body of research on the neural control of immunity and inflammation. However, it is not known whether the nervous system can regulate the production of inflammatory myeloid cells from hematopoietic progenitor cells in disease conditions. Myeloid
T-helper signals restore B-cell receptor signaling in autoreactive anergic B cells by upregulating CD45 phosphatase activity.
Szodoray P
The Journal of Allergy and Clinical Immunology, 138(3), 839-851 (2016)
The soluble cytoplasmic tail of CD45 (ct-CD45) in human plasma contributes to keep T cells in a quiescent state.
Puck A
European Journal of Immunology, 47(1), 193-205 (2017)
Ondřej Kodet et al.
International journal of molecular sciences, 22(13) (2021-07-21)
Therapy targeting immune checkpoints represents an integral part of the treatment for patients suffering from advanced melanoma. However, the mechanisms of resistance are responsible for a lower therapeutic outcome than expected. Concerning melanoma, insufficient stimulation of the immune system by
Xiaoguang Wang et al.
Experimental and therapeutic medicine, 22(4), 1140-1140 (2021-09-11)
Pancreatic cancer (PC) is a highly malignant tumor type with a high early metastasis rate and no obvious symptoms. Gemcitabine is a first-line chemotherapeutic drug for PC. Since there is no distinct method to determine the efficacy of chemotherapy with
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service