SAB4502482
Anti-PTGER3 antibody produced in rabbit
affinity isolated antibody
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Synonym(s):
EP3 subtype, PGE receptor, PGE2-R, Prostaglandin E2 receptor EP3 subtype, Prostanoid EP3 receptor
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 43 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000
immunofluorescence: 1:100-1:500
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PTGER3(5733)
General description
The PTGER3 (prostaglandin E receptor 3) gene is mapped to human chromosome 1p31.1 and encodes a Gαi coupled receptor protein. It is predominantly localized to the brain in the neurons and activated glial cells. Anti-PTGER3 antibody detects endogenous levels of total PTGER3 protein.
Immunogen
The antiserum was produced against synthesized peptide derived from human PTGER3.
Immunogen Range: 16-65
Immunogen Range: 16-65
Biochem/physiol Actions
Prostaglandin E receptor 3 (PTGER3) serves as a receptor for prostaglandin (PG) E1 and E2, to carry out a number of physiological processes. PTGER3 specifically functions to reduce adenylyl cyclase action. It is involved in the activation of the Ras signaling pathway.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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Inhibition of prostaglandin E2 receptor EP3 mitigates thrombin-induced brain injury
Han, X, et al.
Journal of Cerebral Blood Flow and Metabolism, 36(6), 1059-1074 (2016)
Tuberin Regulates Prostaglandin Receptor-Mediated Viability, via Rheb, in mTORC1-Hyperactive Cells
Li C, et al.
Molecular Cancer Research (2017)
The key residue within the second extracellular loop of human EP3 involved in selectively turning down PGE 2-and retaining PGE 1-mediated signaling in live cells
Akasaka H
Archives of Biochemistry and Biophysics, 616, 20-29 (2017)
Loss of heterozygosity at chromosome 1p in different solid human tumours: association with survival.
Ragnarsson G
British Journal of Cancer, 79(9-10), 1468-1474 (1999)
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