SAB4502329
Anti-AMPK α antibody produced in rabbit
affinity isolated antibody
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Synonym(s):
5′-AMP-activated protein kinase, AAPK1, AMPK α-1 chain, AMPK-α1, catalytic α-1 chain
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 62 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... AAPK1(5562)
General description
Anti-AMPK α antibody detects endogenous levels of total AMPK α protein.
The AMPK α (protein kinase AMP-activated catalytic subunit α1) gene is located on human chromosome 5p13.1. The gene is evolutionarily conserved.
Immunogen
The antiserum was produced against synthesized peptide derived from human AMPK alpha.
Immunogen Range: 140-189
Immunogen Range: 140-189
Application
Anti-AMPK α antibody produced in rabbit has been used in immunohistochemistry.
Biochem/physiol Actions
The AMPK α (protein kinase AMP-activated catalytic subunit α1) gene is associated with the regulation of cell cycle, cell proliferation, energy metabolism and inhibition of rapamycin-pathway. Therefore, it plays an important role in carcinogenesis. From recent studies, variation in the gene is known to be involved in gastric cancer. AMPK α might induce anti-inflammatory response in adipose tissue, upon its activation resulting in a beneficial effect in obesity. Decreased cellular ATP or AMP is known to stimulate AMPK enzyme. Activated AMPK stimulates pathways such as mitochondrial biogenesis, glucose transport in muscle and mitochondrial biogenesis, in order to replenish cellular ATP. On the other hand, it prevents anabolic pathways that consume ATP including biosynthesis of fatty acid and cholesterol as well as adipogenesis. The AMPK signaling pathway is generally stimulated in response to stress, energy deficiency and/or oxygen inadequacy.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
AMPK and HIF signaling pathways regulate both longevity and cancer growth: the good news and the bad news about survival mechanisms.
Salminen A
Biogerontology, 17(4), 655-680 (2016)
A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1.
Shi Y
Nature Genetics, 43(12), 1215-1218 (2011)
Additive interactions between PRKAA1 polymorphisms and Helicobacter pylori CagA infection associated with gastric cancer risk in Koreans.
Eom SY
Cancer Medicine, 5(11), 3236-3335 (2016)
Interaction of renin-angiotensin system and adenosine monophosphate-activated protein kinase signaling pathway in renal carcinogenesis of uninephrectomized rats.
Yang KK
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 39(5) (2017)
Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation.
Mancini SJ
Molecular and Cellular Endocrinology, 440, 44-56 (2017)
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