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Merck
CN

SAB4502260

Anti-PPAR-α antibody produced in rabbit

affinity isolated antibody

Synonym(s):

NR1C1, PPAR-α, PPARA Peroxisome proliferator-activated receptor α

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 52 kDa

species reactivity

human, rat, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

NCBI accession no.

Q07869

UniProt accession no.

Q07869

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PPARA(5465)

General description

Anti-PPAR-α antibody detects endogenous levels of total PPAR-α protein.
The PPAR-α (peroxisome proliferator-activated receptor α) gene is mapped to human chromosome 22q13.31. Ppar-α is localized to the nucleus.

Immunogen

The antiserum was produced against synthesized peptide derived from human PPAR-alpha.

Immunogen Range: 6-55

Biochem/physiol Actions

PPAR-α (peroxisome proliferator-activated receptor α) is a receptor transcription factor that inhibits inflammation, by preventing the nuclear factor κB activation. Omega-3 long-chain polyunsaturated fatty acids is known to be the ligand that brings out the anti-inflammatory action of Ppar-α. Ppar-α is involved in epidermal proliferation and differentiation and therefore serves as a skin barrier. PPARα mediates lipid metabolism by inducing fatty acid oxidation and also regulates glucose metabolism. Variation in the gene is observed in schizophrenia.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
210975

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Eupatilin with PPAR? agonistic effects inhibits TNF?-induced MMP signaling in HaCaT cells.
Jung Y
Biochemical and Biophysical Research Communications, 493(1), 220-226 (2017)
Role of PPAR? in the attenuation of bile acid-induced apoptosis by omega-3 long-chain polyunsaturated fatty acids in cultured hepatocytes.
Tillman EM
Pediatric Research, 79(5), 754-758 (2016)
Microdeletions involving chromosomes 12 and 22 associated with syndromic Duane retraction syndrome.
Abu-Amero KK
Ophthalmic Genetics, 35(3), 162-169 (2014)
An association between the PPAR?-L162V polymorphism and nicotine dependency among patients with schizophrenia.
Nadalin S
Comprehensive Psychiatry, 70, 118-124 (2016)
Nutrient-sensing nuclear receptors PPAR? and FXR control liver energy balance.
Preidis GA
The Journal of Clinical Investigation, 127(4), 1193-1201 (2017)
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