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Key Documents

Safety Information

SAB4502234

Sigma-Aldrich

Anti-Cytochrome c antibody produced in rabbit

affinity isolated antibody

Synonym(s):

CYC, CYCS, Cytochrome c

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1 EA
CN¥6,218.64

CN¥6,218.64

Available to ship onApril 27, 2025Details

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1 EA
CN¥6,218.64

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

CN¥6,218.64

Available to ship onApril 27, 2025Details

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 11 kDa

species reactivity

human, rat, mouse

concentration

~1 mg/mL

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particle size

5 μm

particle size

3 μm

particle size

3 μm

particle size

3 μm

matrix

silica gel, high purity, spherical base material, fully porous particle

matrix

silica gel, high purity, spherical particle platform, fully porous particle

matrix

silica gel, high purity, spherical particle platform, fully porous particle

matrix

silica gel, high purity, spherical particle platform, fully porous particle

separation technique

hydrophilic interaction (HILIC), reversed phase, normal phase

separation technique

reversed phase

separation technique

reversed phase

separation technique

reversed phase

matrix active group

cyano phase

matrix active group

C18 (octadecyl) phase

matrix active group

C18 (octadecyl) phase

matrix active group

C18 (octadecyl) phase

technique(s)

HPLC: suitable, LC/MS: suitable

technique(s)

HPLC: suitable, LC/MS: suitable

technique(s)

HPLC: suitable, LC/MS: suitable

technique(s)

HPLC: suitable, LC/MS: suitable

pore size

180 Å

pore size

120 Å

pore size

120 Å

pore size

120 Å

General description

Anti-Cytochrome c antibody detects endogenous levels of total Cytochrome c protein.
The cytochrome c gene is mapped to human chromosome 7p15.3. The encoded protein consists of two thioether present between heme and two cysteine residues included in a CXXCH motif (highly conserved). It is localized to mitochondrial intermembrane space.

Immunogen

The antiserum was produced against synthesized peptide derived from human Cytochrome c.

Immunogen Range: 10-59

Application

Anti-Cytochrome c, N-terminal antibody produced in rabbit has been used in western blot analysis.

Biochem/physiol Actions

Cytochrome c is a water-soluble intermediary of electron transport chain. It acts as an ROS (reactive oxygen species) scavenger, and involved in redox-mediated protein import and apoptosis. Cytochrome c has peroxidase activity, contributing towards intrinsic pathway of apoptosis.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    310170

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    Find documentation for the products that you have recently purchased in the Document Library.

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    Biosynthesis of Single Thioether c-Type Cytochromes Provides Insight into Mechanisms Intrinsic to Holocytochrome c Synthase (HCCS).
    Babbitt SE
    Biochemistry, 56(26), 3337-3346 (2017)
    Nesrine Ebrahim et al.
    International journal of molecular sciences, 23(11) (2022-06-11)
    Trastuzumab (Trz) is a humanized monoclonal antibody targeting epidermal growth factor receptor 2 (HER2; ErbB2). The combined administration of Trz and doxorubicin (DOX) has shown potent anti-cancer efficacy; however, this regimen may be accompanied by severe cardiac toxicity. Mesenchymal stem
    Eman Mohamed Fath et al.
    Forensic toxicology (2024-08-09)
    The goal of the current study was to clarify the potential molecular mechanism underlying the protective effects of silymarin (SIL) administration against diazinon-induced subacute nephrotoxicity, with a special emphasis on the role of the Kelch-like-associated protein-1 (Keap1)-nuclear factor erythroid 2-related
    5'RUNX1-3'USP42 chimeric gene in acute myeloid leukemia can occur through an insertion mechanism rather than translocation and may be mediated by genomic segmental duplications.
    Zagaria A
    Molecular Cytogenetics, 7(1):66, 1-8 (2014)
    Enhancing the peroxidase activity of cytochrome c by mutation of residue 41: implications for the peroxidase mechanism and cytochrome c release.
    Josephs TM
    The Biochemical Journal, 458(2), 259-265 (2014)
    View All Related Papers

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