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Safety Information

SAB4502210

Sigma-Aldrich

Anti-PLD1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Choline phosphatase 1, Phosphatidylcholine-hydrolyzing phospholipase D1, Phospholipase D1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 124 kDa

species reactivity

mouse, human, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000
immunohistochemistry: 1:50-1:100

NCBI accession no.

Q13393

UniProt accession no.

Q13393

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PLD1(5337)

General description

Anti-PLD1 Antibody detects endogenous levels of total PLD1 protein.
The PLD1 (phospholipase D1) gene is mapped to human chromosome 3q26.31. The protein encoded consists of pleckstrin homology and phox homology domains.

Immunogen

The antiserum was produced against synthesized peptide derived from human PLD1.

Immunogen Range: 527-576

Biochem/physiol Actions

PLD1 (phospholipase D1) is responsible for the hydrolysis of phosphatidylcholine to yield phosphatidic acid and choline. It controls EGFR (epidermal growth factor receptor) endocytosis, which is associated with the process of cell proliferation, differentiation, migration and survival. PLD1 regulates the metabolic flexibility of cancer cells to help it maintain its viability and proliferation in response to stress. Upregulation of the gene is observed in gastric cancer. PLD1 might play an important role in allergic disorders such as asthma.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
210723

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MicroRNA-638 inhibits cell proliferation by targeting phospholipase D1 in human gastric carcinoma.
Zhang J
Protein & cell, 6(9), 680-688 (2015)
Phospholipase D1-regulated autophagy supplies free fatty acids to counter nutrient stress in cancer cells.
Cai M
Cell Death & Disease, 7(11), 1-10 (2016)
The pleckstrin homology domain of phospholipase D1 accelerates EGFR endocytosis by increasing the expression of the Rab5 effector, rabaptin-5.
Park MH
Experimental & Molecular Medicine, 18;47, 1-8 (2015)
Comprehensive copy number profiles of breast cancer cell model genomes.
Shadeo A
Breast Cancer Research, 8(1):R9, 1-14 (2006)
The TLR4-associated phospholipase D1 activation is crucial for Der f 2-induced IL-13 production.
Choi HJ
Allergy, 70(12), 1569-1579 (2015)

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