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SAB4502184

Sigma-Aldrich

Anti-Progesterone Receptor antibody produced in rabbit

affinity isolated antibody

Synonym(s):

NR3C3, PGR, PR, PRGR, nuclear receptor 3C3

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About This Item

MDL number:
MFCD00239723
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 98 kDa

species reactivity

rat, mouse, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100

NCBI accession no.

P06401

UniProt accession no.

P06401

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PGR(5241)

Related Categories

General description

Anti-Progesterone receptor antibody detects endogenous levels of total progesterone receptor protein.
The progesterone receptor (PR) gene is mapped to human chromosome 11q22–23. The gene encodes for two isoforms, namely PR-A and PR-B, each of which is transcribed from a specific promoter region. The encoded receptor belongs to the family of steroid hormone receptors.

Immunogen

The antiserum was produced against synthesized peptide derived from human Progesterone Receptor.

Immunogen Range: 261-310

Application

Anti-Progesterone receptor antibody produced in rabbit has been used in western blotting and immunohistochemistry.

Biochem/physiol Actions

Progesterone receptor (PR) mediates the actions of progesterone which is essential to maintain pregnancy. PR is known to regulate the genes involved in the process of cell cycle, cell adhesion, invasion, differentiation, proliferation, inflammation, and apoptosis. PR expression might serve as a biomarker in axillary lymph node (ALN) metastasis. Abnormal expression of PR is observed in breast cancer.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Absent progesterone receptor expression in the lymph node metastases of ER-positive, HER2-negative breast cancer is associated with relapse on tamoxifen.
Snell CE
Journal of Clinical Pathology, 70(11), 954-960 (2017)
CCAAT/enhancer binding protein ? negatively regulates progesterone receptor expression in human glioblastoma cells.
Hansberg-Pastor V
Molecular and Cellular Endocrinology, 439, 317-327 (2017)
Rapid impact of progesterone on the neuronal growth cone.
Olbrich L.
Endocrinology, 154(10), 3784-3795 (2013)
No association between the progesterone receptor gene polymorphism (+331G/a) and the risk of breast cancer: an updated meta-analysis.
Qi XL
BMC Medical Genetics, 18(1):123, 1-7 (2017)
Akt regulates progesterone receptor B-dependent transcription and angiogenesis in endometrial cancer cells.
Lee II
Oncogene, 35(39), 5191-5201 (2016)
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