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SAB4502163

Sigma-Aldrich

Anti-Mucin-14 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Endomucin, Endomucin-2, Gastric cancer antigen Ga34, MUC-14, Mucin-14

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 27 kDa

species reactivity

human, rat, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000
immunofluorescence: 1:100-1:500

NCBI accession no.

Q9ULC0

UniProt accession no.

Q9ULC0

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... EMCN(51705)

General description

The EMCN (endomucin) gene is mapped to human chromosome 4q24. It encodes a 80−120kDa transmembrane sialomucin. Mucin-14 is predominantly expressed in heart, kidney and lungs. Endomucin is a surface glycoprotein localized to the endothelial cells. Mucin-14 is a type 1 integral protein. Endomucin possesses 261 amino acid residues and a serine/threonine-rich extracellular domain. Anti-Mucin-14 Antibody detects endogenous levels of total Mucin-14 protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human Mucin-14.

Immunogen Range: 201-250

Biochem/physiol Actions

Mucin-14 controls lymphocyte adhesion and its expression is associated with the pathogenesis of rheumatoid arthritis. Mucin-14 associated with O-glycans enables it to promote cell−matrix and cell-cell interactions.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Endomucin inhibits VEGF-induced endothelial cell migration, growth, and morphogenesis by modulating VEGFR2 signaling
Park WC, et al.
Scientific reports, 7(1), 17138-17138 (2017)
Alisar Zahr et al.
Nature communications, 7, 10363-10363 (2016-02-03)
Endomucin is a membrane-bound glycoprotein expressed luminally by endothelial cells that line postcapillary venules, a primary site of leukocyte recruitment during inflammation. Here we show that endomucin abrogation on quiescent endothelial cells enables neutrophils to adhere firmly, via LFA-1-mediated binding
Kazumasa Nishimoto et al.
The Journal of rheumatology, 38(2), 221-228 (2010-12-17)
Endomucin, an endothelial-specific sialomucin, is thought to facilitate "lymphocyte homing" to synovial tissues, resulting in the major histopathologies of rheumatoid arthritis (RA). We examined the association between RA susceptibility and the gene coding endomucin, EMCN. Association studies were conducted with
A Novel Acquired t (2; 4)(q36. 1; q24) with a Concurrent Submicroscopic del (4)(q23q24) in An Adult with Polycythemia Vera
Kjeldsen E
Cancers, 10(7), 214-214 (2018)

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