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Key Documents

Safety Information

SAB4502149

Sigma-Aldrich

Anti-PDGF Receptor β antibody produced in rabbit

affinity isolated antibody

Synonym(s):

CD140b, PDGF-R-β, PDGFR, PDGFR-β, kinase PDGFR-β

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About This Item

MDL number:
MFCD00164777
UNSPSC Code:
12352203
NACRES:
NA.41
Pricing and availability is not currently available.

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 123 kDa

species reactivity

rat, mouse, human

concentration

~1 mg/mL

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Anti-PDGF Receptor β antibody produced in rabbit affinity isolated antibody

SAB4502149

Anti-PDGF Receptor β antibody produced in rabbit

Anti-PDGFR β antibody produced in rabbit affinity isolated antibody

SAB4502148

Anti-PDGFR β antibody produced in rabbit

Anti-PDGFRB (Ab-751) antibody produced in rabbit affinity isolated antibody

SAB4300478

Anti-PDGFRB (Ab-751) antibody produced in rabbit

Anti-Phospho-PDGFR beta-Y751 antibody produced in rabbit

SAB5700369

Anti-Phospho-PDGFR beta-Y751 antibody produced in rabbit

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

-

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

species reactivity

rat, mouse, human

species reactivity

mouse, human, rat

species reactivity

rat, human

species reactivity

human, mouse

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

General description

The PDGFRB (platelet-derived growth factor receptor β) gene is mapped to human chromosome 5q32. The encoded protein is a cell surface tyrosine kinase receptor. Anti-PDGF receptor β antibody detects endogenous levels of total PDGF receptor β protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human PDGF Receptor beta.

Immunogen Range: 718-767

Biochem/physiol Actions

PDGFRB (platelet-derived growth factor β) has its key role in cell proliferation, differentiation and survival. It also mediates cell movement and tissue repair mechanism. PDGFβ functions as a mitogen, by binding to the PDGF receptor β. Variation in PDGFRB gene leads to a number of cancer types including glioblastoma, dermatofibrosarcoma, medulloblastoma and endocrine pancreatic tumor. PDGFR-β signaling pathway, can thus serve as an important target for cancer therapy.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品
  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    217194

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    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

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    Tyrosines-740/751 of PDGFRbeta contribute to the activation of Akt/Hif1alphaTGFbeta nexus to drive high glucose-induced glomerular mesangial cell hypertrophy
    Das F, et al.
    Cellular Signalling, 42(6), 44-53 (2018)
    Mutations in PDGFRB cause autosomal-dominant infantile myofibromatosis.
    Martignetti J A, et al.
    American Journal of Human Genetics, 92(6), 1001-1007 (2013)
    The 3?-end region of the human PDGFR-beta core promoter nuclease hypersensitive element forms a mixture of two unique end-insertion G-quadruplexes
    Onel B, et al.
    Biochim. Biophys. Acta Gen. Subj., 1862(4), 846-854 (2018)
    Nigella sativa L. seed extracts promote wound healing progress by activating VEGF and PDGF signaling pathways: An in vitro and in silico study.
    Palanisamy, et al.
    F1000Research, 12, 436-436 (2023)

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