SAB4502077
Anti-Parkin antibody produced in rabbit
affinity isolated antibody
Synonym(s):
PARK2, PRKN, PRKN2, Parkinson disease protein 2, Parkinson juvenile disease protein 2
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 51 kDa
species reactivity
human, mouse, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PARK2(5071)
General description
Anti-Parkin Antibody detects endogenous levels of total Parkin protein.
Parkin RBR E3 ubiquitin protein ligase (PARK2) is a putative tumor suppressor gene. It possesses an amino-terminal region containing the Ubl (ubiquitin like) domain and a carboxy-terminal region with four zinc coordinating domains. Parkin is a 465 amino acid protein, which is part of the ubiquitin-proteasome system that targets proteins for degradation. The gene encoding it is localized on human chromosome 6q25.2-q27.
Immunogen
The antiserum was produced against synthesized peptide derived from human Parkin.
Immunogen Range: 1-50
Immunogen Range: 1-50
Application
Anti-Parkin antibody produced in rabbit has been used in western blotting.
Biochem/physiol Actions
The expression of parkin RBR E3 ubiquitin protein ligase (PARK2) has been found to be altered in various malignancies. Parkin has a neuroprotective E3 ligase activity and polyubiquitylates proteins before degradation. Mutations in the gene encoding it have been linked to autosomal recessive juvenile parkinson (ARJP) disease.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Genetic and epigenetic alterations affecting PARK-2 expression in cervical neoplasm among North Indian patients
Naseem A, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 39(6), 1010428317703635-1010428317703635 (2017)
High tidal volume induces mitochondria damage and releases mitochondrial DNA to aggravate the ventilator-induced lung injury
Lin J, et al.
Frontiers in Immunology, 9(6), 1477-1477 (2018)
PARK2 polymorphisms predict disease progression in patients infected with hepatitis C virus
Al-Qahtani AA, et al.
Annals of Hepatology, 15(6), 824-833 (2017)
A comprehensive computational study on pathogenic mis-sense mutations spanning the RING2 and REP domains of Parkin protein.
Biswas R and Bagchi A
Gene, 610, 49-58 (2017)
Jin-Yuan Lin et al.
Frontiers in immunology, 9, 1477-1477 (2018-07-19)
This study aimed to determine whether high tidal volume (HTV) induce mitochondria damage and mitophagy, contributing to the release of mitochondrial DNA (mtDNA). Another aim of the present study was to investigate the role and mechanism of mtDNA in ventilator-induced
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