SAB4502019
Anti-NOTCH1 (Cleaved-Val1754) antibody produced in rabbit
affinity isolated antibody
Synonym(s):
NOTC1, Notch homolog 1, neurogenic locus notch 1, notch 1 (translocation-associated), translocation-associated (Drosophila) (TAN1)
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 110 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
application(s)
research pathology
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
proteolytically cleaved (Val1754)
Gene Information
human ... NOTCH1(4851)
General description
The NOTCH1 gene is mapped to human chromosome 9q34 and encodes a member of the NOTCH family of proteins. The gene encodes a large transmembrane protein that contains an extracellular domain with 36 tandem epidermal growth factor (EGF)-like repeats and three cysteine-rich Notch/LIN-12 repeats, a six ankyrin repeat-containing intracellular domain, and a transactivation domain.
Anti-NOTCH1 (Cleaved-Val1754) Antibody detects endogenous levels of fragment of activated NOTCH1 (Cleaved-Val1754) protein.
Anti-NOTCH1 (Cleaved-Val1754) Antibody detects endogenous levels of fragment of activated NOTCH1 (Cleaved-Val1754) protein.
Immunogen
The antiserum was produced against synthesized peptide derived from human Notch 1.
Immunogen Range: 1735-1784
Immunogen Range: 1735-1784
Application
Anti-NOTCH1 (Cleaved-Val1754) antibody produced in rabbit has been used in immunohistochemistry (IHC).
Biochem/physiol Actions
The Notch1 protein is a transmembrane receptor that induces pluripotent progenitor cells to form T-cells and facilitates the assembly of pre–T cell receptor complexes in immature thymocytes. It participates in an intracellular signaling pathway that regulates cellular differentiation, cell fate and lateral inhibition. Mutations in this gene have been associated with human blood cancers, abnormal cardiovascular calcification, aortic valve disease, and human T cell acute lymphoblastic leukemia.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Takaya Shiraishi et al.
International journal of molecular medicine, 44(4), 1574-1584 (2019-08-01)
The Notch receptor serves a fundamental role in the regulation of cell fate determination through intracellular signal transmission. Mutation of the Notch receptor results in abnormal active signaling, leading to the development of diseases involving abnormal cell growth, including malignant
Yan Li et al.
Bioengineered, 12(2), 10183-10193 (2021-12-08)
As the second most common cancer among women, cervical cancer is a huge threat to their health all over the world. Integral membrane protein 2A (ITM2A), a member of the Type II Integral Membrane protein (ITM2) family, has been reported
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
Weng A P, et al.
Science, 306(5694), 269-271 (2004)
Notch 1 is a valuable therapeutic target against cell survival and proliferation in clear cell renal cell carcinoma.
Zhuang Z, et al.
Oncology Letters, 14(3), 3437-3444 (2017)
Mutations in NOTCH1 cause aortic valve disease.
Garg V, et al.
Nature, 437(7056), 270-270 (2005)
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