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Safety Information

SAB4501654

Sigma-Aldrich

Anti-Keratin 8 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

CK 8, CK8, CYK8, Cytokeratin endo A, K2C8

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 53 kDa

species reactivity

rat, human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P05787

UniProt accession no.

P05787

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... KRT8(3856)

Related Categories

General description

Keratin 8 (KRT8) is an intermediate filaments protein, that is located on human chromosome 12q13.

Immunogen

The antiserum was produced against synthesized peptide derived from human Keratin 8.

Immunogen Range: 401-450

Application

Anti-Keratin 8, C-Terminal antibody has been used in immunofluorescence.

Biochem/physiol Actions

Keratins act as cytoprotective proteins. KRT8 plays an important role in the pathophysiology of RPE (retinal pigment epithelium). It plays a hepatoprotective role against mechanical and toxic injury.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Loss of c-KIT expression in thyroid cancer cells
Franceschi S, et al.
PLoS ONE (2017)
Keratin 8 Y54H and G62C mutations are not associated with liver disease
Halangk J, et al.
Journal of medical Genetics (2004)
Marie Alexandra Albaret et al.
Cancers, 10(11) (2018-11-21)
Accumulating evidence supports the remarkable presence at the membrane surface of cancer cells of proteins, which are normally expressed in the intracellular compartment. Although these proteins, referred to as externalized proteins, represent a highly promising source of accessible and druggable
Alan T Tang et al.
PLoS biology, 21(2), e3001989-e3001989 (2023-02-07)
Angiotensin-converting enzyme 2 (ACE2) is the cell-surface receptor for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). While its central role in Coronavirus Disease 2019 (COVID-19) pathogenesis is indisputable, there remains significant debate regarding the role of this transmembrane carboxypeptidase in
WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation
Xu M, et al.
Nature Communications (2017)
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