SAB4501527
Anti-IGFBP-3 antibody produced in rabbit
affinity isolated antibody
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All Photos(2)
Synonym(s):
IBP-3, IBP3, IGF-binding protein 3, IGFBP3, Insulin-like growth factor binding protein 3 precursor
Recommended Products
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 31 kDa
species reactivity
human, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... IGFBP3(3486)
General description
Insulin-like growth factor-binding protein 3 (IGFBP3), a multifunctional protein belongs to the insulin-like growth factor binding proteins (IGFBPs) superfamily. The IGFBP3 gene is located on human chromosome 7p12. Anti-IGFBP-3 antibody detects endogenous levels of total IGFBP-3 protein.
Immunogen
The antiserum was produced against synthesized peptide derived from human IGFBP-3.
Immunogen Range: 151-200
Immunogen Range: 151-200
Biochem/physiol Actions
Insulin-like growth factor-binding protein 3 (IGFBP3) can stimulate cell growth and apoptosis. It participates in DNA repair. Patients with rheumatoid arthritis show an increased level of IGFBP3 in the serum and synovial fluid. It is involved in the proliferation of stress-induced senescence in human endometrium-derived mesenchymal stem cells (MESCs). IGFBP3 can suppress insulin-like growth factor-1 (IGF-1) signaling and modulate lung carcinogenesis and cell proliferation.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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Chia-Chia Chao et al.
Life sciences, 265, 118758-118758 (2020-11-15)
Insulin-like growth factor (IGF) signaling has been documented in several human malignancies and is thought to contribute to cellular differentiation and migration, as well as malignant progression. A major binding molecule of IGF, IGF-binding protein 3 (IGFBP-3), regulates multiple IGF
Roman E Ushakov et al.
Biochemical and biophysical research communications, 531(2), 133-139 (2020-08-13)
Insulin-like growth factor binding protein 3 (IGFBP3) is a multifunctional protein, able either to stimulate the cell growth or to promote apoptosis. In particular, IGFBP3 plays significant role in propagation of stress-induced senescence in human endometrium-derived mesenchymal stem cells (MESCs)
K Eggermann et al.
Annales de genetique, 42(2), 117-121 (1999-08-06)
Maternal uniparental disomy (UPD) of chromosome 7 has recently been reported in about 10% of Silver-Russell (SRS) patients. It can therefore be concluded that at least one gene on chromosome 7 is imprinted and mutations in this gene/these genes might
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