SAB4501488
Anti-GPR109 antibody produced in rabbit
affinity isolated antibody
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Synonym(s):
G-protein coupled receptor 109B, G-protein coupled receptor HM74, G-protein coupled receptor HM74B, GPR109B, Nicotinic acid receptor 2
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 44 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... HCAR3(8843)
General description
Anti-GPR109 antibody detects endogenous levels of total GPR109 protein.
GPR109B (G-protein coupled receptor 109B) is also called as hydroxycarboxylic acid receptor 3 (HCA3) and HM74 (G-protein coupled receptor). It belongs to the subfamily of G-protein-coupled receptors (GPCR). GPR109B is expressed in adipose tissue, lung, spleen and peripheral blood leukocytes. It is mapped to human chromosome 12q24.31.
Immunogen
The antiserum was produced against synthesized peptide derived from human GPR109.
Immunogen Range: 285-334
Immunogen Range: 285-334
Biochem/physiol Actions
GPR109B (G-protein coupled receptor 109B) helps to carry out the activities of D-Phe and D-Trp on neutrophils. HCA3 receptors helps to activate ERK1/2 through PTX (Pertussis toxin)-sensitive Gi (inhibitory G) protein-dependent pathway.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
Activated human hydroxy-carboxylic acid receptor-3 signals to MAP kinase cascades via the PLC-dependent PKC and MMP-mediated EGFR pathways
Zhou Q, et al.
British Journal of Pharmacology, 166(6), 1756-1773 (2012)
Nicotinic acid receptor abnormalities in human skin cancer: implications for a role in epidermal differentiation
Bermudez Y, et al.
PLoS ONE (2011)
Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B
Irukayama-Tomobe Y, et al.
Proceedings of the National Academy of Sciences of the USA, 106(10), 3930-3934 (2009)
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