SAB4501438
Anti-APC antibody produced in rabbit
affinity isolated antibody
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All Photos(2)
Synonym(s):
APC, APC protein, Adenomatous polyposis coli protein, DP2.5, adenomatous polyposis of the colon gene
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 311 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... APC(324)
General description
Adenomatous polyposis coli (APC) is a tumour suppressor gene. It is located on human chromosome 5q21.
Anti-APC Antibody detects endogenous levels of total APC protein.
Immunogen
The antiserum was produced against synthesized peptide derived from human APC.
Immunogen Range: 2794-2843
Immunogen Range: 2794-2843
Biochem/physiol Actions
Adenomatous polyposis coli (APC) plays an important role in cell division, adhesion and migration. Mutations in APC gene is associated with colorectal carcinomas.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Adenomatous polyposis coli (APC) regulates miR17-92 cluster through ?-catenin pathway in colorectal cancer.
Li Y
Oncogene, 35(35), 4558-4568 (2016)
Epigenetic regulation of APC in the molecular pathogenesis of gallbladder cancer
Tekcham DS, et al.
The Indian Journal of Medical Research, 143(Suppl 1) (2016)
Lorenzo Alibardi
Journal of morphology, 283(5), 677-688 (2022-02-24)
Lizard tail regeneration is likely regulated by the balanced activity of oncogenes and tumor suppressors that control cell proliferation avoiding tumorigenic degeneration. One of the main tumor suppressor genes present in the regenerating tail is the "adenomatous polyposis coli (apc)"
Hongfei Ge et al.
Molecular neurobiology (2021-10-13)
Spinal cord injury (SCI), a devastating neurological impairment, usually imposes a long-term psychological stress and high socioeconomic burden for the sufferers and their family. Recent researchers have paid arousing attention to white matter injury and the underlying mechanism following SCI.
Till Ringel et al.
Cell stem cell, 26(3), 431-440 (2020-03-07)
Forward genetic screens with genome-wide CRISPR libraries are powerful tools for resolving cellular circuits and signaling pathways. Applying this technology to organoids, however, has been hampered by technical limitations. Here we report improved accuracy and robustness for pooled-library CRISPR screens by
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