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Safety Information

SAB4501367

Sigma-Aldrich

Anti-Histone H2A antibody produced in rabbit

affinity isolated antibody

Synonym(s):

H2A.1b, H2A/c, H2A/d, H2A/i, H2A/n

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 14 kDa

species reactivity

human, rat, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000
immunohistochemistry: 1:50-1:100

NCBI accession no.

P0C0S8

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... H2AC13(8329)

General description

Anti-Histone H2A Antibody detects endogenous levels of total Histone H2A protein.
Histones have an important role in the organization and modification of chromatin. The nucleosome is the basic unit of the chromatin. It is made up of two molecules each of histones H2A, H2B, H3 and H4 wrapped with approximately 146bp of DNA. Histone H1 binds to the nucleosomes at the DNA entry and exit points and stabilizes them. Histone cluster 1 H2A family member I (HIST1H2AI) or H2A/c is a replication-dependent isoform of histone H2A. It stabilizes the histone core octamer and the gene encoding it is localized on human chromosome 6p22.1.

Immunogen

The antiserum was produced against synthesized peptide derived from human Histone H2A.

Immunogen Range: 81-130

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

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Certificates of Analysis (COA)

Lot/Batch Number
218247

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Increasing the complexity of chromatin: functionally distinct roles for replication-dependent histone H2A isoforms in cell proliferation and carcinogenesis
Rajbir Singh
Nucleic Acids Research (2013)
The histone variant H3.3 marks active chromatin by replication-independent nucleosome assembly.
Ahmad K and Henikoff S
Molecular and Cellular Biochemistry (2002)
Core histones H2B and H4 are mobilized during infection with herpes simplex virus 1.
Conn KL
Journal of Virology (2011)
A Comprehensive View of the Epigenetic Landscape Part I: DNA Methylation, Passive and Active DNA Demethylation Pathways and Histone Variants
Neurotoxicity Research (2015)

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