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SAB4501319

Sigma-Aldrich

Anti-GRM2 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

GPRC1B, GRM2, MGLUR2, Metabotropic glutamate receptor 2, mGluR2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 95 kDa

species reactivity

rat, human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100

NCBI accession no.

Q14416

UniProt accession no.

Q14416

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GRM2(2912)

Related Categories

General description

Anti-GRM2 Antibody detects endogenous levels of total GRM2 protein.
Metabotropic glutamate receptor 2 (MGLUR2/GRM2) with 872 amino acids, is encoded by the gene mapped to human chromosome 3. GRM2 belongs to the class c of G-protein-coupled receptor (GPCRs) family. It is expressed mainly in the central nervous system (CNS) of rat brain and widely expressed in human adult and fetal brain. GRM2 is characterized with an α-helical helix 8 (H8) domain.

Immunogen

The antiserum was produced against synthesized peptide derived from human GRM2.

Immunogen Range: 241-290

Biochem/physiol Actions

Metabotropic glutamate receptor (MGLUR2) is involved in the glutamatergic system in the brain. Overexpression of glutamate in brain areas such as the prefrontal cortex, hippocampus and amygdala leads to anxiety and schizophrenia, activation of MGLUR2 in these areas reduces the excitatory neurotransmission, therefore mGlu2 receptor might be considered as a potential target for the treatment of these diseases. GRM2 signaling inhibits adenylyl cyclase (AC) activity. GRM2 is required for the modulation of synaptic transmission.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

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Membrane-sensitive conformational states of helix 8 in the metabotropic Glu2 receptor, a class C GPCR.
Bruno A, et al.
PLoS ONE, 7(8), e42023-e42023 (2012)
Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling.
El Moustaine D, et al.
Proceedings of the National Academy of Sciences of the USA, 109(40), 16342-16347 (2012)
Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat.
Ohishi H, et al.
Neuroscience, 53(4), 1009-1018 (1993)
A Farinha et al.
British journal of pharmacology, 172(9), 2383-2396 (2015-01-13)
The activation of the metabotropic glutamate receptor 2 (mGlu2 ) reduces glutamatergic transmission in brain regions where excess excitatory signalling is implicated in disorders such as anxiety and schizophrenia. Positive allosteric modulators (PAMs) can provide a fine-tuned potentiation of these
P J Flor et al.
The European journal of neuroscience, 7(4), 622-629 (1995-04-01)
A cDNA encoding the human metabotropic glutamate receptor type 2 (hmGluR2) was isolated from human brain cDNA libraries by cross-hybridization with rat mGluR2 probes. The deduced amino acid sequence of the human mGluR2 receptor consists of 872 residues and shows

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