SAB4501301
Anti-NMDAR1 antibody produced in rabbit
affinity isolated antibody
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All Photos(3)
Synonym(s):
GLURZ1, GRIN1, Glutamate [NMDA] receptor subunit ζ 1 precursor, N-methyl-D-aspartate receptor, NMD-R1
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 105 kDa
species reactivity
mouse, human, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... GRIN1(2902)
General description
N-methyl-d-aspartate receptor (NMDAR1) is a subtype of the ionotropic glutamate receptors (iGluRs). It is coded by GRIN1 gene. It is located on human chromosome 9q34.3. NMDAR1is expressed in epidermal melanocytes.
Anti-NMDAR1 antibody detects endogenous levels of total NMDAR1 protein.
Immunogen
The antiserum was produced against synthesized peptide derived from human NMDAR1.
Immunogen Range: 856-905
Immunogen Range: 856-905
Application
Anti-NMDAR1, C-Terminal antibody has been used in western blot analysis.
Biochem/physiol Actions
N-methyl-d-aspartate receptor (NMDAR1) plays an important role in the pathophysiology of schizophrenia, bipolar disorder and depression. Mutations in GRIN1 gene results in severe intellectual disability, hypotonia, hyperkinetic and stereotyped movements, and epilepsy.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
De novo GRIN1 mutations: An emerging cause of severe early infantile encephalopathy
Zehavi Y, et al.
European Journal of Medical Genetics, 60(6), 317-320 (2017)
The activation of N-methyl-d-aspartate receptors downregulates transient outward potassium and L-type calcium currents in rat models of depression
Liu X, et al.
American Journal of Physiology. Cell Physiology, 313(2), C187-C196 (2017)
The effect of the NMDA receptor-dependent signaling pathway on cell morphology and melanosome transfer in melanocytes
Ni J, et al.
Journal of Dermatological Science, 84(3), 296-304 (2016)
Xin Liu et al.
American journal of physiology. Cell physiology, 313(2), C187-C196 (2017-06-02)
Major depression is an important clinical factor in ventricular arrhythmia. Patients diagnosed with major depression overexpress N-methyl-d-aspartate receptors (NMDARs). Previous studies found that chronic NMDAR activation increases susceptibility to ventricular arrhythmias. We aimed to explore the mechanisms by which NMDAR
Evidence that the N-methyl-D-aspartate subunit 1 receptor gene (GRIN1) confers susceptibility to bipolar disorder
Mundo E, et al.
Molecular Psychiatry, 8(2), 241-241 (2003)
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