SAB4501295
Anti-GLUR2 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
GluR-2, GluR-B, GluR-K2, Glutamate receptor 2, Glutamate receptor ionotropic
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 98 kDa
species reactivity
human, mouse, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... GRIA2(2891)
General description
Anti-GLUR2 Antibody detects endogenous levels of total GLUR2 protein.
GLUR2 (glutamate receptor 2) is coded by gria2 gene. It is mapped to human chromosome 4q32. It is abundantly expressed in the brain.
Immunogen
The antiserum was produced against synthesized peptide derived from human GluR2.
Immunogen Range: 834-883
Immunogen Range: 834-883
Application
Anti-GLUR2, C-Terminal antibody has been used in electron microscopy.
Biochem/physiol Actions
Presence of the glutamate receptor 2 (GluR2) subunit prevents calcium influx through AMPA-receptor complexes. Deletion of this subunit results in enhanced hippocampal long-term potentiation. As such, AMPA receptors play crucial roles in normal neuronal activity, including synaptic plasticity, synaptic scaling, homeostatic synaptic plasticity, learning and memory, as well as in synaptogenesis and the formation of neuronal circuitry.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Involvement of AMPA receptor GluR2 subunits in stimulus-reward learning: evidence from glutamate receptor gria2 knock-out mice
Mead AN and Stephens DN
The Journal of Neuroscience, 23 (2003)
Excitatory synaptic function and plasticity is persistently altered in ventral tegmental area dopamine neurons after prenatal ethanol exposure
Hausknecht K, et al.
Neuropsychopharmacology, 40 (2015)
A nomenclature for ligand-gated ion channels
Collingridge GL, et al.
Neuropharmacology, 56 (2009)
Hu Peng et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 44(38) (2024-08-16)
Ribbon synapses of inner hair cells (IHCs) are uniquely designed for ultrafast and indefatigable neurotransmission of the sound. The molecular machinery ensuring the efficient, compensatory recycling of the synaptic vesicles (SVs), however, remains elusive. This study showed that hair cell
Specificity protein 4 (Sp4) regulates the transcription of AMPA receptor subunit GluA2 (Gria2)
Priya A, et al.
Biochimica et Biophysica Acta (2014)
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