SAB4501175
Anti-Connexin 43 antibody produced in rabbit
affinity isolated antibody
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Synonym(s):
CX43, CXA1, CXN-43, Connexin 43, Gap junction 43 kDa heart protein
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 43 kDa
species reactivity
mouse, human, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... GJA1(2697)
General description
Anti-Connexin 43 Antibody detects endogenous levels of total Connexin 43 protein.
Connexin 43 (Cx43) is also known as GJA1 (gap junction protein α 1) and belongs to a large family of homologous connexin proteins. It has an intracellular N-terminus, four transmembrane domains, two extracellular loops, one cytoplasmic loop and an intracellular C-terminus. It is located on human chromosome 6q22-q23.
Immunogen
The antiserum was produced against synthesized peptide derived from human Connexin 43.
Immunogen Range: 333-382
Immunogen Range: 333-382
Biochem/physiol Actions
Mutations in Connexin 43 (Cx43) gene result in pleiotropic phenotype of oculodentodigital dysplasia. Connexin 43 participates in the multiplication and differentiation of mature T cells. It also participates in the secretion and manufacturing of cytokines. It helps to release lactate from glycolytic pancreatic ductal adenocarcinoma cells.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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Mohammad El-Harakeh et al.
World journal of gastroenterology, 28(40), 5845-5864 (2022-11-11)
Inflammatory bowel disease (IBD) constitutes a substantial risk factor for colorectal cancer. Connexin 43 (Cx43) is a protein that forms gap junction (GJ) complexes involved in intercellular communication, and its expression is altered under pathological conditions, such as IBD and
Connexin-43 channels are a pathway for discharging lactate from glycolytic pancreatic ductal adenocarcinoma cells
Dovmark TH, et al.
Oncogene, 36, 4538-4550 (2017)
Connexin 43 (GJA1) mutations cause the pleiotropic phenotype of oculodentodigital dysplasia
Paznekas WA, et al.
American Journal of Human Genetics, 72, 408-418 (2003)
Layal El-Hajjar et al.
International journal of molecular sciences, 24(3) (2023-02-12)
Gap-junction-forming connexins are exquisitely regulated by post-translational modifications (PTMs). In particular, the PTM of connexin 43 (Cx43), a tumor suppressor protein, regulates its turnover and activity. Here, we investigated the interaction of Cx43 with the ubiquitin-related modifier 1 (URM-1) protein
Camilla Schinner et al.
JCI insight, 5(9) (2020-05-08)
Arrhythmogenic cardiomyopathy (AC) is a genetic disease causing arrhythmia and sudden cardiac death with only symptomatic therapy available at present. Mutations of desmosomal proteins, including desmoglein-2 (Dsg2) and plakoglobin (Pg), are the major cause of AC and have been shown
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