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Merck
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SAB4501013

Anti-OPN3 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

ECPN, Encephalopsin, OPN3, Opsin-3, Panopsin

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, WB
Citations:
6

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 44 kDa

species reactivity

human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000, western blot: 1:500-1:1000

NCBI accession no.

Q9H1Y3

UniProt accession no.

Q9H1Y3

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... OPN3(23596)

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General description

Anti-OPN3 Antibody detects endogenous levels of total OPN3 protein.
Opsin 3 (OPN3) is also termed as encephalopsin or panopsin. It is a member of the encephalopsin/tmt-opsin subfamily. It is expressed in brain, liver, placenta, heart and pancreatic tissues. The OPN3 gene is located on human chromosome 1q43.

Immunogen

The antiserum was produced against synthesized peptide derived from human OPN3.

Immunogen Range: 161-210

Biochem/physiol Actions

Opsin3 controls the apoptotic pathway and makes hepatocellular carcinoma cells fragile to 5-fluorouracil treatment. OPN3 plays an important role in oncogenesis and drug resistance. It also plays crucial roles in various physiological and pathological processes.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
61487

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Bioinformatic Analysis of Human OPN3 Alternative Promoters Associated with Cancer.
Al-Obaide MA, et al.
Applied Mathematics & Information Sciences, 10, 1223-1229 (2016)
Curcumin alleviated oxidation stress injury by mediating osteopontin in nephrolithiasis rats.
Huang, et al.
Acta Cirurgica Brasileira / Sociedade Brasileira Para Desenvolvimento Pesquisa em Cirurgia, 38, e380223-e380223 (2023)
Opsin3 sensitizes hepatocellular carcinoma cells to 5-fluorouracil treatment by regulating the apoptotic pathway.
Jiao J, et al.
Cancer Letters, 320(1), 96-103 (2012)
Encephalopsin (OPN3) protein abundance in the adult mouse brain.
Nissila J, et al.
Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 198(11), 833-839 (2012)
Multiple hits for the association of uterine fibroids on human chromosome 1q43.
Aissani B, et al.
PLoS ONE, 8(3), e58399-e58399 (2013)
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