SAB4500839
Anti-FAP-1 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
PTP-BAS, PTP1E, PTPL1, PTPN13, α subunit, DPPIV, FAPA, SEPRASE, fibroblast activation protein
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About This Item
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 87 kDa
species reactivity
human, mouse, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... FAP(2191)
Related Categories
General description
Fibroblast activation protein 1 (FAP-1) is a membrane-associated protein tyrosine phosphatase. It is made up of an ezrin-like cytoskeleton binding domain, six PSD95/Dlg/Z-1 homology (PDZ) domains, and a leucine zipper motif. The FAP-1 gene is located on the human chromosome at 4q21.3. Anti-FAP-1 antibody detects endogenous levels of total FAP-1 protein.
Immunogen
The antiserum was produced against synthesized peptide derived from human FAP-1.
Immunogen Range: 331-380
Immunogen Range: 331-380
Application
Anti-FAP-1 antibody produced in rabbit has been used in western blotting (1: 500) and immunohistochemistry (10 μg/ml).
Biochem/physiol Actions
Fibroblast activation protein 1 (FAP-1) is involved in tumorigenesis, apoptosis, cancer progression, and insulin signaling. It acts as a prognostic marker in high-grade serous ovarian cancer and breast cancer. Overexpression of the FAP-1 gene is associated with several human cancers such as hepatocellular, pancreatic, ovarian, hematological, and colon cancer. Mutations in the FAP-1 gene lead to liver and lung cancer.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Xiaoming Bai et al.
Cell communication and signaling : CCS, 21(1), 242-242 (2023-09-19)
Cancer-associated fibroblasts (CAFs) are critically involved in tumor progression by maintaining extracellular mesenchyma (ECM) production and improving tumor development. Cyclooxygenase-2 (COX-2) has been proved to promote ECM formation and tumor progression. However, the mechanisms of COX-2 mediated CAFs activation have
Upregulation of miR-200c-3p induced by NaF promotes endothelial apoptosis by activating Fas pathway.
Yuting Jiang et al.
Environmental pollution (Barking, Essex : 1987), 266(Pt 1), 115089-115089 (2020-07-07)
Fluoride has been considered as a risk factor of cardiovascular disease due to its endothelial toxicology. However, the mechanism underlying the endothelial toxicity of fluoride has not been clearly illustrated. MiR-200c-3p was strongly linked with endothelial function and its level
Vladimir N Ivanov et al.
Molecular and cellular biology, 23(10), 3623-3635 (2003-05-02)
As revealed by intracellular pools of nonactive Fas (Apo-1), export of Fas to the cell surface is often impaired in human tumors, thereby inactivating Fas ligand-mediated apoptosis. Here, we demonstrate that association with Fas-associated phosphatase 1 (FAP-1) attenuates Fas export
Mohamed Hamyeh et al.
Theranostics, 10(3), 1016-1032 (2020-01-16)
Clinical data suggest that the protein tyrosine phosphatase PTPN13 exerts an anti-oncogenic effect. Its exact role in tumorigenesis remains, however, unclear due to its negative impact on FAS receptor-induced apoptosis. Methods: We crossed transgenic mice deleted for PTPN13 phosphatase activity
Sang-Ok Lee et al.
Biochemical and biophysical research communications, 478(3), 1205-1210 (2016-08-22)
Protein tyrosine phosphatase-Basophil (PTP-Bas) is a membrane-associated protein tyrosine phosphatase with five PDZ domains and is involved in apoptosis, tumorigenesis, and insulin signaling. The interaction between PTP-Bas and tandem-PH-domain-containing protein 1/2 (TAPP1/2) plays an essential role in the regulation of
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