SAB4500810
Anti-Estrogen Receptor-α antibody produced in rabbit
affinity isolated antibody
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All Photos(2)
Synonym(s):
ER, ESR, ESR1, ESTR, ESTRA
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 66 kDa
species reactivity
human, rat, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ESR1(2099)
General description
Anti-Estrogen Receptor-α Antibody detects endogenous levels of total Estrogen Receptor-α protein.
Estrogen receptor α(ERα) is a member of the nuclear receptor superfamily. It is also known as ESR1 (estrogen receptor). It is located on human chromosome 6q25.1.
Immunogen
The antiserum was produced against synthesized peptide derived from human Estrogen Receptor-alpha.
Immunogen Range: 81-130
Immunogen Range: 81-130
Application
Anti-Estrogen Receptor-α antibody has been used in immunohistochemistry and western blotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Immunohistochemistry (1 paper)
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Immunohistochemistry (1 paper)
Biochem/physiol Actions
Estrogen receptor α(ERα) is involved in immune and inflammatory response. Aberrations in ESR1 results in Mayer-Rokitansky-Küster-Hauser syndrome that is associated with the congenital absence of the uterus and the upper two-thirds of the vagina.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
MYC Amplification as a Predictive Factor of Complete Pathologic Response to Docetaxel-based Neoadjuvant Chemotherapy for Breast Cancer
Pereira CBL, et al.
Clinical Breast Cancer, 17(3), 188-194 (2017)
Prognostic and predictive significance of MYC and KRAS alterations in breast cancer from women treated with neoadjuvant chemotherapy
Pereira CB, et al.
PLoS ONE, 8(3) (2013)
ESR1 is co-expressed with closely adjacent uncharacterised genes spanning a breast cancer susceptibility locus at 6q25.1
Dunbier AK, et al.
PLoS Genetics, 7(4) (2011)
17β-Estradiol Attenuates Hematoma Expansion through ERα/Sirt1/NF-?B Pathway in Hyperglycemic Intracerebral Hemorrhage Mice
Zheng Y, et al.
Stroke, 46(2), 485-485 (2015)
Cynthia Brito Lins Pereira et al.
PloS one, 8(3), e60576-e60576 (2013-04-05)
Breast cancer is a complex disease, with heterogeneous clinical evolution. Several analyses have been performed to identify the risk factors for breast cancer progression and the patients who respond best to a specific treatment. We aimed to evaluate whether the
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