SAB4500718
Anti-EGFR antibody produced in rabbit
affinity isolated antibody
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ERBB1, Epidermal growth factor receptor, Epidermal growth factor receptor precursor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 134 kDa
species reactivity
human, rat, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... EGFR(1956)
General description
Epidermal growth factor receptor (EGFR, ErbB1) is a transmembrane protein that exerts tyrosine kinase activity upon ligand induced activation. EGFR can be activated by binding EGF or at least six other structurally related protein ligands, including transforming growth factor-α (TGF-α), heparin-binding EGF-like growth factor (HB-EGF), betacellulin (BTC), amphiregulin, epiregulin and epigen. The gene encoding it is localized on human chromosome 7p11.2. Anti-EGFR Antibody detects endogenous levels of total EGFR protein.
Immunogen
The antiserum was produced against synthesized peptide derived from human EGFR.
Immunogen Range: 1139-1188
Immunogen Range: 1139-1188
Biochem/physiol Actions
Upon activation by ligands, epidermal growth factor receptor (EGFR, ErbB1) initiates a signaling cascade which includes dimerization and internalization, tyrosine phosphorylation, DNA synthesis of target genes, and, ultimately, cell proliferation. EGFR signaling plays a role in the growth and differentiation of normal cells, but elevated EGFR activity is correlated with the development and pathogenesis of certain cancers.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
新产品
Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
Molecular mechanisms of resistance to the EGFR monoclonal antibody cetuximab.
Cancer Biology & Therapy, 11(9), 777-792 (2011)
A chromosomal region 7p11.2 transcript map: its development and application to the study of EGFR amplicons in glioblastoma.
Neuro-Oncology, 4(2), 86-94 (2002)
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