SAB4500631
Anti-CHOP, N-Terminal antibody produced in rabbit
affinity isolated antibody
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All Photos(3)
Synonym(s):
C/EBP-homologous protein, DDIT3, DNA-damage inducible transcript 3, GADD153, Growth arrest and DNA-damage-inducible protein GADD153
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 19 kDa
species reactivity
human, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... DDIT3(1649)
General description
Anti-CHOP Antibody detects endogenous levels of total CHOP protein.
CCAAT/enhancer-binding protein homologous protein (CHOP) is a transcriptional regulator, that is located on human chromosome 12q13. It is also known as DNA damage inducible transcript 3 (DDIT3).
Immunogen
The antiserum was produced against synthesized peptide derived from human CHOP.
Immunogen Range: 15-64
Immunogen Range: 15-64
Application
Anti-CHOP, N-Terminal antibody has been used in protein extraction and western blotting.
Biochem/physiol Actions
CCAAT/enhancer-binding protein homologous protein (CHOP) controls endoplasmic reticulum (ER) stress-mediated apoptosis. It also modulates the transcription of cellular lipid metabolism. CHOP controls chronic kidney disease–induced vascular calcification.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
Induction of Apoptosis Coupled to Endoplasmic Reticulum Stress through Regulation of CHOP and JNK in Bone Marrow Mesenchymal Stem Cells from Patients with Systemic Lupus Erythematosus
Guo G, et al.,
Journal of immunology research (2015)
Contributions of cytogenetics and molecular cytogenetics to the diagnosis of adipocytic tumors
Nishio J
Journal of Biomedicine and Biotechnology (2011)
Protective role of magnesium isoglycyrrhizinate in non-alcoholic fatty liver disease and the associated molecular mechanisms
Xu Q, et al.
International Journal of Molecular Medicine, 38(1), 275-282 (2016)
Sujata Saraswat Ohri et al.
Journal of neurotrauma, 29(3), 579-588 (2011-09-22)
Manipulation of various components of the endoplasmic reticulum (ER) stress response (ERSR) has led to functional recovery in diabetes, cancer, and several neurodegenerative diseases, indicating its use as a potential therapeutic intervention. One of the downstream pro-apoptotic transcription factors activated
Endoplasmic reticulum stress effector CCAAT/enhancer-binding protein homologous protein (CHOP) regulates chronic kidney disease-induced vascular calcification
Miyazaki-Anzai S, et al.
Journal of the American Heart Association (2014)
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