SAB4500493
Anti-p38 MAPK antibody produced in rabbit
affinity isolated antibody
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MAP kinase MXI2, MAP kinase p38, MAPK14, kinase p38-α
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 41 kDa
species reactivity
human, rat, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... MAPK14(1432)
General description
Anti-p38 MAPK Antibody detects endogenous levels of total p38 MAPK protein.
p38 mitogen-activated protein kinase (MAPK), also known as, mitogen-activated protein kinase 14 (MAPK14)/ p38α, is encoded by the gene mapped on human chromosome 6p21.31. The encoded protein is a Ser/Thr kinase composed of 90 to 360 residues. p38α MAPK is ubiquitously expressed. It is found in the cytosol, but it can translocate to the nucleus.
Immunogen
The antiserum was produced against synthesized peptide derived from human p38 MAPK.
Immunogen Range: 147-196
Immunogen Range: 147-196
Application
Anti-p38 MAPK antibody produced in rabbit has been used in western blot analysis.
Biochem/physiol Actions
p38 mitogen-activated protein kinase (MAPK)/MAPK14 (mitogen-activated protein kinase 14) participates in resistance of colon cancer cells to camptothecin-related drugs. This protein is required for the growth of embryos. This gene controls proliferation, differentiation, cell death, adhesion, migration, as well as the response to stress and many metabolic pathways. Genetic variation in p38α leads to deletion or overproduction of myelosuppressive cytokines and result in certain bone marrow failure syndromes.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Resveratrol-induced autophagy promotes survival and attenuates doxorubicin-induced cardiotoxicity
International Immunopharmacology, 32, 1-7 (2016)
Triptolide Protects Against Ischemic Stroke in Rats
Inflammation, 38(4), 1617-1623 (2015)
MAPK14 (mitogen-activated protein kinase 14)
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2011)
MAPK14/p38? confers irinotecan resistance to TP53-defective cells by inducing survival autophagy.
Autophagy, 8(7), 1098-1112 (2012)
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