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Merck
CN

SAB4500465

Anti-CRHR1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

CRF-R, CRF1, CRH-R 1, Corticotropin-releasing factor receptor 1, Corticotropin-releasing hormone receptor 1

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

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Product Name

Anti-CRHR1 antibody produced in rabbit, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 50 kDa

species reactivity

rat, mouse, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

NCBI accession no.

P34998

UniProt accession no.

P34998

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... CRHR1(1394)

Application

Anti-CRHR1 antibody has been used in immunoprecipitation and western blotting.

Biochem/physiol Actions

CRHR1 (corticotropin releasing factor receptor 1) blocks the multiplication of endocrine-related cancer cell lines. It helps to initiate signal transduction pathways, that controls various functions like stress, reproduction, immune response and obesity.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

General description

Anti-CRHR1 Antibody detects endogenous levels of total CRHR1 protein.
CRHR1 (corticotropin releasing factor receptor 1) is a member of the G-protein-coupled receptor superfamily of brain-gut neuropeptides. It is highly expressed in the amygdala, hippocampus and frontal cortex. It has 13 exons and located on human chromosome 17q12-q22.

Immunogen

The antiserum was produced against synthesized peptide derived from human CRHR1.

Immunogen Range: 75-124

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
61072

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Association analysis of polymorphisms of the CRHR1 gene with infantile spasms
Yang G, et al.
Molecular Medicine Reports, 12(2), 2539-2546 (2015)
Family Economic Hardship, Corticotropin-Releasing Hormone Receptor Polymorphisms, and Depressive Symptoms in Rural African-American Youths
Chen YF and Brody GH
The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine, 57(2), 235-240 (2015)
Urocortinergic system in the testes of normal and cryptorchid dogs
Squillacioti C, et al.
Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft, 207, 91-96 (2016)
Urocortin protects chondrocytes from NO-induced apoptosis: a future therapy for osteoarthritis?
Intekhab-Alam NY, et al.
Cell Death & Disease (2013)
Dynamic Alterations of miR-34c Expression in the Hypothalamus of Male Rats after Early Adolescent Traumatic Stress
Li C, et al.
Neural Plast. (2016)
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