SAB4500435
Anti-Claudin 3 antibody produced in rabbit
affinity isolated antibody
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Synonym(s):
CPE-R 2, CPE-receptor 2, Claudin-3, Clostridium perfringens enterotoxin receptor 2, Ventral prostate.1 protein homolog
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 23 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:40000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CLDN3(1365)
General description
Anti-Claudin 3 Antibody detects endogenous levels of total Claudin 3 protein.
Claudin-3 (CLDN3) is a tetraspanin transmembrane protein, that is mapped to human chromosome 7q11.23.
Immunogen
The antiserum was produced against synthesized peptide derived from human Claudin 3.
Immunogen Range: 171-220
Immunogen Range: 171-220
Application
Anti-Claudin 3, C-Terminal antibody has been used in immunofluorescence and western blotting.
Biochem/physiol Actions
In submandibular gland, claudin-3 (CLDN3) controls paracellular permeability with the help of TNF-α(tumor necrosis factor α). High level expression of CLDN3 improves the malignant ability of colorectal cancer cells. It participates in the organization and activities of tight junctions (TJs).
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Claudin-3 overexpression increases the malignant potential of colorectal cancer cells: roles of ERK1/2 and PI3K-Akt as modulators of EGFR signaling
de Souza WF, et al.
PLoS ONE (2013)
Generation of specific monoclonal antibodies against the extracellular loops of human claudin-3 by immunizing mice with target-expressing cells
Ando H, et al.
Bioscience, Biotechnology, and Biochemistry, 79(8), 1272-1279 (2015)
Evidence for a role of claudin 2 as a proximal tubular stress responsive paracellular water channel
Wilmes A, et al.
Toxicology and Applied Pharmacology, 279(2), 163-172 (2014)
Claudin-3 is required for modulation of paracellular permeability by TNF-? through ERK1/2/slug signaling axis in submandibular gland
Mei M, et al.
Cellular Signalling, 27(10), 1915-1927 (2015)
Katharina M C Klee et al.
Human genetics, 139(10), 1247-1259 (2020-04-20)
Congenital diarrheal disorders (CDD) comprise > 50 monogenic entities featuring chronic diarrhea of early-onset, including defects in nutrient and electrolyte absorption, enterocyte polarization, enteroendocrine cell differentiation, and epithelial integrity. Diarrhea is also a predominant symptom in many immunodeficiencies, congenital disorders of glycosylation
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