SAB4500433
Anti-Claudin 4 antibody produced in rabbit
affinity isolated antibody
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All Photos(2)
Synonym(s):
CLD4, CLDN4, CPE- receptor, Claudin-4, Clostridium perfringens enterotoxin receptor
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 22 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CLDN4(1364)
General description
The CLDN4 (claudin 4) gene is mapped to human chromosome 7q11.23. The encoded protein is an integral member, localized to tight junction. It is also expressed in the epithelial basolateral membrane.
Immunogen
The antiserum was produced against synthesized peptide derived from human Claudin 4.
Immunogen Range: 160-209
Immunogen Range: 160-209
Biochem/physiol Actions
CLDN4 (claudin 4) is associated with epithelial differentiation, and is widely implicated in carcinomas. Its expression is considered to differentiate carcinoma with that of sarcoma. Claudin 4 expression is implicated in gastric cancer induced by Helicobacter pylori infection. It contributes to invasion, metastasis and prognosis of the disease. The CLDN4 gene is known to be overexpressed in a number of chemoresistant and metastatic cancer. Its localization to the tight junction prevents paracellular diffusion. Along with this, the extracellular loop interaction mediated by claudin 4 with the neighbouring cells makes it a differentiation marker.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
Role of TGF-beta-induced Claudin-4 expression through c-Jun signaling in non-small cell lung cancer
Rachakonda G, et al.
Cellular Signalling, 28(10), 1537-1544 (2016)
Claudin-1,-3 and-4 proteins and mRNA expression in benign and malignant breast lesions: a research study
Thokes AM, et al.
Breast Cancer Research, 7(2), R296-R296 (2005)
Claudin-4 activity in ovarian tumor cell apoptosis resistance and migration
Hicks DA, et al.
BMC Cancer, 16(1), 788-788 (2016)
Claudin-4 expression distinguishes SWI/SNF complex-deficient undifferentiated carcinomas from sarcomas
Schaefer IM, et al.
Modern Pathology, 30(4), 539-539 (2017)
TLR2 activation induced by H. pylori LPS promotes the differential expression of claudin-4, -6, -7 and -9 via either STAT3 and ERK1/2 in AGS cells
Chavarria-Velazquez CO, et al.
Immunobiology, 223(1), 38-48 (2018)
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