SAB4500352
Anti-Histone H3 antibody produced in rabbit
affinity isolated antibody
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Synonym(s):
H3/a, H3/c, H3/d, H3/f, H3/h
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 15 kDa
species reactivity
human, rat, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... HIST1H3A(8350)
General description
Anti-Histone H3 Antibody detects endogenous levels of total Histone H3 protein.
Mammals contain three main classes of histone H3 variants: the replicative histones (H3.1 and H3.2), the replacement histone (H3.3) and the centromeric histone (Cenp-A). Histone H3 is located on human chromosome 6p22.
Immunogen
The antiserum was produced against synthesized peptide derived from human Histone H3.
Immunogen Range: 1-50
Immunogen Range: 1-50
Application
Anti-Histone H3, N-Terminal antibody has been used in western blotting and enzyme-linked immunosorbent assay (ELISA).
Biochem/physiol Actions
Histone proteins are basic building blocks of chromatin. Histone H3 K27M mutations in adult cerebellar high-grade gliomas. It controls protein-protein interactions to induce binding of trans-acting factors that “drive” chromatin condensation.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Histone Demethylation and Toll?like Receptor 8?Dependent Cross?Talk in Monocytes Promotes Transdifferentiation of Fibroblasts in Systemic Sclerosis Via Fra?2.
Ciechomska M, et al.
Arthritis and Rheumatism, 68(6), 1493-1504 (2016)
Dihydromyricetin protects against liver ischemia/reperfusion induced apoptosis via activation of FOXO3a-mediated autophagy.
Chen Y, et al.
Oncotarget, 7(47), 76508-76508 (2016)
Parissa C Monem et al.
PLoS genetics, 19(1), e1010577-e1010577 (2023-01-11)
As ribosomes translate the genetic code, they can encounter a variety of obstacles that hinder their progress. If ribosomes stall for prolonged times, cells suffer due to the loss of translating ribosomes and the accumulation of aberrant protein products. Thus
Omar Ramírez-Nuñez et al.
Journal of neurochemistry, 158(2), 482-499 (2021-04-28)
Nucleocytosolic transport, a membrane process, is impaired in motor neurons in amyotrophic lateral sclerosis (ALS). This study analyzes the nuclear lipidome in motor neurons in ALS and examines molecular pathways linked to the major lipid alterations. Nuclei were obtained from
Jingjing Yao et al.
Neuropathology : official journal of the Japanese Society of Neuropathology, 41(3), 183-190 (2021-02-19)
We investigated the risk factors for diffuse midline gliomas of the spinal cord (DMGSCs). Seventy patients with spinal cord gliomas in two hospitals were analyzed retrospectively. Sixty-nine patients that underwent surgery achieved partial or gross total removal. The patients were
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