SAB4301254
Anti-phospho-PKC α (pTyr657) antibody produced in rabbit
affinity isolated antibody
Synonym(s):
KPCA, PKC III, PKC-A, PKC-alpha
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
80 kDa
species reactivity
human
concentration
1.0 mg/mL
technique(s)
western blot: 1:500-1:1000 (Cell Lysate)
isotype
IgG
accession no.
NP_002728.1.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pTyr657)
Gene Information
human ... PRKCA(5578)
General description
Protein kinase C α (PRKCA) is encoded by the gene mapped to human chromosome 17q24.2. The encoded protein is a member of the serine/threonine-specific protein kinase family.
Immunogen
Peptide sequence around phosphorylation site of tyrosine 658(F-S-Y(p)-V-N) derived from Human PKC α.
Biochem/physiol Actions
Protein kinase C α (PRKCA) is a serine-threonine kinase. It is associated with tumorigenesis, invasion, apoptosis, differentiation, angiogenesis and metastasis. Downregulation of PKCA inhibits the invasion of urinary bladder, colon, renal cell, breast carcinomas, multiple myeloma, glioma and endometrial cancer cells. In endothelial cells, PRKCA-mediated phosphorylation of TRPC1 (transient receptor potential cation channel subfamily C member 1) regulates store operated Ca2+ entry.
The antibody detects endogenous levels of PKC α only when phosphorylated at tyrosine 658.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Identification of a Novel, Recurrent SLC44A1?PRKCA Fusion in Papillary Glioneuronal Tumor
Bridge JA, et al.
Brain Pathology, 23, 121-128 (2013)
Reduction of protein kinase C α (PKC-α) promote apoptosis via down-regulation of Dicer in bladder cancer.
Jiang Z, et al.
Journal of Cellular and Molecular Medicine, 19, 1085-1093 (2015)
Inhibition of protein kinase Calpha prevents endothelial cell migration and vascular tube formation in vitro and myocardial neovascularization in vivo.
Wang A, et al.
Circulation Research, 90, 609-616 (2002)
MZF-1/Elk-1 Complex Binds to Protein Kinase C? Promoter and Is Involved in Hepatocellular Carcinoma.
Yue CH, et al.
PLoS ONE, 10 (2015)
PKC? promotes the mesenchymal to amoeboid transition and increases cancer cell invasiveness.
Vaskovicova K, et al.
BMC Cancer (2015)
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