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Merck
CN

SAB4301113

Anti-HRAS Antibody

rabbit polyclonal

Synonym(s):

CTLO, HAMSV, HRAS1, K-RAS, v-Ha-ras Harvey rat sarcoma viral oncogene homolog

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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Product Name

Anti-RAS antibody produced in rabbit, affinity isolated antibody

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

21 kDa

species reactivity

mouse, rat, human

concentration

0.7 mg/mL

technique(s)

western blot: 1:200-1:1000 (Cell Lysate)

isotype

IgG

accession no.

NP_001123914.1

UniProt accession no.

P01112

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... HRAS(3265)

General description

Ras is a proto-oncogene and the gene encoding it is localized on human chromosome 11p15.5. It is a 21 kDa protein and is part of the small GTP-binding proteins superfamily.

Immunogen

Synthetic peptide corresponding to a region derived from 60-74 amino acids of Human v-Ha-ras Harvey rat sarcoma viral oncogene homolog

Biochem/physiol Actions

Ras is a guanine-nucleotide binding protein that couples tyrosine kinase receptor signals to mitogen activated protein (MAP) kinase cascade. It has an important role in cell growth. Ras is a substrate for farnesyltransferase (FTase) and when farnesylated, it is anchored to the membrane. Membrane localization of Ras is crucial for its cellular activity. Inhibition of Ras farnesylation is a target for anti-cancer drug development.
The antibody detects endogenous level of total RAS protein.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.7mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
352231153

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Germline mutations in HRAS proto-oncogene cause Costello syndrome.
Aoki Y, et al.
Nature Genetics, 37(10), 1038-1038 (2005)
Human mucin gene MUC5B, the 10.7-kb large central exon encodes various alternate subdomains resulting in a super-repeat structural evidence for a 11p15. 5 gene family.
Desseyn J L, et al.
The Journal of Biological Chemistry, 272(6), 3168-3178 (1997)
Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development.
Rowinsky E K, et al.
Journal of Clinical Oncology, 7(11), 3631-3652 (1999)

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