SAB4301078
Anti-TDP2 antibody produced in rabbit
affinity isolated antibody
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All Photos(2)
Synonym(s):
AD022, EAP2, EAPII, TTRAP, hTDP2
UNSPSC Code:
12352203
NACRES:
NA.41
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biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
41 kDa
species reactivity
human, mouse
concentration
2.6 mg/mL
technique(s)
immunohistochemistry: 1:50- 1:200
western blot: 1:200-1:1000 (Cell Lysate)
isotype
IgG
accession no.
NP_057698.2
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TDP2(51567)
General description
Tyrosyl DNA phosphodiesterase-2 (TDP2) is a multi-functional protein and is also called as TTRAP (TNF receptor-associated protein). It is a 5′- tyrosyl DNA phosphodiesterase that belongs to the PML NB (promyelocytic leukemia nuclear body) protein family. TDP2 is mapped to human chromosome 6p22.
Specificity
The antibody detects endogenous levels of total TDP2 protein.
Immunogen
Synthetic peptide corresponding to a region derived from internal residues of human tyrosyl-DNA phosphodiesterase 2
Biochem/physiol Actions
Chromosomal translocations stimulated by DNA topoisomerase II at the time of gene transcription is repressed by tyrosyl DNA phosphodiesterase-2 (TDP2). It is essential to preserve the chromosome stability in human cells. TDP2 participates in cell proliferation, apoptosis and the repair of DNA damage. It promotes cell cycle arrest and apoptosis in osteosarcoma cells.
Features and Benefits
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Physical form
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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Overexpression of TTRAP inhibits cell growth and induces apoptosis in osteosarcoma cells.
Zhou C, et al.
Bmb Reports, 46(2), 113-113 (2013)
TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription.
Gomez-Herreros F, et al.
Nature Communications, 8(1), 233-233 (2017)
Tyrosyl-DNA-phosphodiesterases (tdp1 and tdp2).
Pommier Y, et al.
DNA Repair, 19, 114-129 (2014)
Henrike Johanna Gothe et al.
Molecular cell, 75(2), 267-283 (2019-06-17)
How spatial chromosome organization influences genome integrity is still poorly understood. Here, we show that DNA double-strand breaks (DSBs) mediated by topoisomerase 2 (TOP2) activities are enriched at chromatin loop anchors with high transcriptional activity. Recurrent DSBs occur at CCCTC-binding factor
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