SAB4300883
Anti-NeuN antibody produced in rabbit
affinity isolated antibody
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Synonym(s):
FLJ56884, FLJ58356, FOX3, HRNBP3, RBFOX3
UNSPSC Code:
12352203
NACRES:
NA.41
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biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
34 kDa
species reactivity
human, mouse, rat
concentration
1.0 mg/mL
technique(s)
western blot: 1:500-1:2000 (Cell Lysate)
isotype
IgG
accession no.
NP_001076044.1
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... RBFOX3(146713)
General description
NeuN (neuronal nuclei), also known as RBFOX3 (RNA binding protein, fox-1 homolog 3), is encoded by the gene mapped to human chromosome 17q25.3. The encoded protein belongs to the RBFOX family of proteins. NeuN is present in nuclei and perinuclear cytoplasm of most of the neurons in the central nervous system (CNS) of mammals.
Specificity
The antibody detects endogenous level of total NeuN protein.
Immunogen
Recombinant protein of human NeuN.
Application
Anti-NeuN antibody produced in rabbit has been used in Immunohistochemical staining.
Biochem/physiol Actions
NeuN (neuronal nuclei)/RBFOX3 (RNA binding protein, fox-1 homolog 3) is a RNA splicing factor. It controls neuronal splicing pathway. NeuN is used as a potential marker of postmitotic neurons in studies of neuronal differentiation and in the evaluation of neuronal status both in norm and pathology. Mutation in the gene is associated with risk of rolandic epilepsy. Studies have shown that in presence of neurological disorders, the protein is mislocalized.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
ETV2 mediates endothelial transdifferentiation of glioblastoma.
Zhao C, et al.
Signal transduction and targeted therapy, 3(1), 4-4 (2018)
Effect of transplantation of olfactory ensheathing cell conditioned medium induced bone marrow stromal cells on rats with spinal cord injury.
Feng L, et al.
Molecular Medicine Reports, 16(2), 1661-1668 (2017)
Electroacupuncture promotes neural stem cell proliferation and neurogenesis in the dentate gyrus of rats following stroke via upregulation of Notch1 expression.
Zhao J, et al.
Molecular Medicine Reports, 12(5), 6911-6917 (2015)
RBFOX and PTBP1 proteins regulate the alternative splicing of micro-exons in human brain transcripts.
Li Y I, et al.
Genome Research, 25(1), 1-13 (2015)
RBFOX1 and RBFOX3 mutations in rolandic epilepsy.
Lal D, et al.
PLoS ONE, 8(9), e73323-e73323 (2013)
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