SAB4300706
Anti-Ring1A antibody produced in rabbit
affinity isolated antibody
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Synonym(s):
Anti-RING1, Anti-RNF1
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
~58 kDa
species reactivity
rat, human, mouse
concentration
1 mg/mL
technique(s)
western blot: 1:500-1:1000
isotype
IgG
immunogen sequence
(I-A-V-S-P)
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... Ring1A(6015)
General description
The antibody detects endogenous level of total Ring1A protein.
Immunogen
Peptide sequence around aa. 35-39 ( I-A-V-S-P), according to the protein NP_002922.2
Features and Benefits
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Target description
Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of ′Lys-119′ of histone H2A, thereby playing a central role in histone code and gene regulation. H2A ′Lys-119′ ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex act via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.
Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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