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SAB4300628

Sigma-Aldrich

Anti-phospho-CK2α (pThr360/Ser362) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-CK2A1, Anti-CKII, Anti-CSNK2A1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~42 kDa

species reactivity

human, rat, mouse

concentration

1 mg/mL

technique(s)

western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(V-P-Tp-P-Sp-P-L)

NCBI accession no.

NM_001903.2

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pThr360/pSer362)

Gene Information

human ... CTNNA1(1495)

General description

The antibody detects endogenous level of CK2 only when phosphorylated at thronine 360.

Immunogen

Peptide sequence around phosphorylation site of threonine360/serine 362 (V-P-Tp-P-Sp-P-L), according to the protein NP_001894.2

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha and alpha′ chains contain the catalytic site. Participates in Wnt signaling. CK2 phosphorylates ′Ser-392′ of p53/TP53 following UV irradiation.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Feng-Ming Yang et al.
The Journal of clinical investigation, 128(6), 2459-2472 (2018-05-08)
Many Toll-like receptors (TLRs) signal through TNF receptor-associated factor 6 (TRAF6) to activate innate immune responses. Here, we show that somatic nuclear autoantigenic sperm protein (sNASP) binds to TRAF6 to prevent TRAF6 autoubiquitination in unstimulated macrophages. Following LPS stimulation, a
Mitsutoshi Ota et al.
Arthritis & rheumatology (Hoboken, N.J.), 72(6), 931-942 (2019-12-01)
We have previously reported that the coactivation of NF-κB and STAT3 in nonimmune cells, including synovial fibroblasts, enhances the expression of NF-κB target genes and plays a role in chronic inflammation and rheumatoid arthritis (RA). This study was undertaken to

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