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SAB4300564

Sigma-Aldrich

Anti-SMAD3 (Ab-208) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-DKFZp586N0721 antibody produced in rabbit, Anti-DKFZp686J10186 antibody produced in rabbit, Anti-HSPC193 antibody produced in rabbit, Anti-HsT17436 antibody produced in rabbit, Anti-SMAD family member 3 antibody produced in rabbit

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~52 kDa

species reactivity

rat, human, mouse

concentration

1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200

isotype

IgG

immunogen sequence

(N-L-S-P-N)

NCBI accession no.

NP_001138574.1

UniProt accession no.

P84022

application(s)

research pathology

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SMAD3(4088)

Related Categories

General description

SMAD3 (SMAD family member 3) is located on chromosome 15q22.

Immunogen

Peptide sequence around aa. 206-210 (N-L-S-P-N), according to the protein SMAD3.

Biochem/physiol Actions

SMAD3 (SMAD family member 3) plays a major role in the intracellular signaling of transforming growth factorβ(TGFβ). Reducing the phosphorylation level of Smad3 helps autophagy to control endothelial-mesenchymal transition. In arterial smooth muscle cells, suppression of SMAD3 results in elevating cell viability.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

Smad3 encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

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Genetic risk factors for the development of allergic disease identified by genome-wide association
Portelli MA, et al.
Clinical and Experimental Allergy, 45(1), 21-31 (2015)
Functional Analysis of a Novel Genome-Wide Association Study Signal in SMAD3 That Confers Protection From Coronary Artery Disease
Turner AW, et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 36(5), 972-983 (2016)
Autophagy regulates Endothelial-Mesenchymal transition by decreasing the phosphorylation level of Smad3
Wang J, et al.
Biochemical and Biophysical Research Communications, 487(3), 740-747 (2017)
Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
Dennler S, et al.
The Embo Journal, 17(11), 3091-3100 (1998)
Lingfang Zeng et al.
Arteriosclerosis, thrombosis, and vascular biology, 35(10), 2134-2144 (2015-09-01)
Smooth muscle cell (SMC) migration and proliferation play an essential role in neointimal formation after vascular injury. In this study, we intended to investigate whether the X-box-binding protein 1 (XBP1) was involved in these processes. In vivo studies on femoral

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