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Merck
CN

SAB4300488

Anti-FGFR1 (Ab-154) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-BFGFR antibody produced in rabbit, Anti-CD331 antibody produced in rabbit, Anti-CEK antibody produced in rabbit, Anti-FGFBR antibody produced in rabbit, Anti-fibroblast growth factor receptor 1 antibody produced in rabbit

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~145 kDa

species reactivity

human, mouse

concentration

1 mg/mL

technique(s)

western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(A-P-Y-W-T)

NCBI accession no.

NP_001167534.1

UniProt accession no.

P11362

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... FGFR1(2260)

Related Categories

General description

FGF encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described.
FGFR1 (fibroblast growth factor receptor 1) gene codes for 9 isoforms of FGFR1. It has 19 exons spanning 55kb DNA. It is located on human chromosome 8p11.1. High level expression of FGFR1 is seen in midfacial membranous ossification sites. It is mostly present in neurons like hippocampal and dentate gyrus neurons.

Immunogen

Peptide sequence around aa. 152-156 (A-P-Y-W-T), according to the protein FGFR1.

Application

Anti-FGFR1 (Ab-154) antibody has been used in western blotting .

Biochem/physiol Actions

FGFR1 (fibroblast growth factor receptor 1) helps in the growth of nervous system. It also controls the skeletal development and bone homeostasis. FGFR1 mutations lead to craniosynostosis and facial abnormalities. Mutation in FGFR1 Ig-like domain II-III linker region (FGFR1 P252R) results in Pfeiffer syndrome.

Features and Benefits

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Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
101821231
951421231

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BBB-Permeable, Neuroprotective, and Neurotrophic Polysaccharide, Midi-GAGR
Makani V, et al.
PLoS ONE, 11(3) (2016)
Contribution of FGFR1 Variants to Craniofacial Variations in East Asians
Adel M, et al.
PLoS ONE, 12(1) (2017)
Vishruti Makani et al.
PloS one, 11(3), e0149715-e0149715 (2016-03-05)
An enormous amount of efforts have been poured to find an effective therapeutic agent for the treatment of neurodegenerative diseases including Alzheimer's disease (AD). Among those, neurotrophic peptides that regenerate neuronal structures and increase neuron survival show a promise in

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