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Merck
CN

SAB4300155

Anti-phospho-HDAC4 (pSer632) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-HA6116 antibody produced in rabbit, Anti-HD4 antibody produced in rabbit, Anti-HDAC-A antibody produced in rabbit, Anti-HDACA antibody produced in rabbit, Anti-histone deacetylase 4 antibody produced in rabbit

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~140 kDa

species reactivity

mouse, rat, human

concentration

1 mg/mL

technique(s)

western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(A-Q-SP-S-P)

NCBI accession no.

NP_006028.2

UniProt accession no.

P56524

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer632)

Gene Information

human ... HDAC4(9759)

General description

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.

Immunogen

Peptide sequence around phosphorylation site of serine 632 (A-Q-S(p)-S-P), according to the protein HDAC4.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Features and Benefits

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Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
871511192

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Nadine Kirschmer et al.
PloS one, 11(12), e0168446-e0168446 (2016-12-20)
The Transient Receptor Potential Channel Subunit 4 (TRPC4) has been considered as a crucial Ca2+ component in cardiomyocytes promoting structural and functional remodeling in the course of pathological cardiac hypertrophy. TRPC4 assembles as homo or hetero-tetramer in the plasma membrane

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