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Merck
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SAB4300124

Anti-phospho-JAK2 (pTyr1007) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-JTK10 antibody produced in rabbit, Anti-Janus kinase 2 (a protein tyrosine kinase) antibody produced in rabbit

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~125 kDa

species reactivity

mouse, rat, human

concentration

1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(K-E-YP-Y-K)

NCBI accession no.

NP_004963.1

UniProt accession no.

O60674

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pTyr1007)

Gene Information

human ... JAK2(3717)

General description

Janus kinase 2(JAK2) mapped on human chromosome 9p24, encodes a tyrosine kinase. The encoded protein is a member of the Jak family of protein. JAK2 is ubiquitously expressed. This protein contains a catalytic domain and protein–protein interaction domain.
Plays a role in leptin signaling and control of body weight.

Immunogen

Peptide sequence around phosphorylation site of tyrosine 1007 (K-E-Y(p)-Y-K), according to the protein JAK2.

Biochem/physiol Actions

Janus kinase 2(JAK2) plays an important role in the activities of cytokines receptors. Overexpression of JAK2 results in neuroblastoma. JAK2 mutations promote primary resistance to PD-1 (anti-programmed death protein 1) blockade therapy. In addition, mutations in the gene has also been observed in polycythaemia vera patients.

Features and Benefits

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Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
871511151

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A TEL-JAK2 Fusion Protein with Constitutive Kinase Activity in Human Leukemia
Lacronique V
Science, 278, 1309-1312 (1997)
Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations.
Shin DS
Cancer Discovery, 7, 188-201 (2017)
Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors
Parganas E
Cell, 93, 385-395 (1998)
Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2.
Joos S
International Journal of Cancer. Journal International Du Cancer, 103, 489-495 (2003)
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
James C
Nature, 434, 1144-1148 (2005)
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