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SAB4300110

Sigma-Aldrich

Anti-phospho-CDK2 (pThr160) antibody produced in rabbit

affinity isolated antibody

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Synonym(s):
Anti-cyclin-dependent kinase 2 antibody produced in rabbit, Anti-p33(CDK2) antibody produced in rabbit
MDL number:
MFCD00675227
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~34 kDa

species reactivity

rat, human, mouse

concentration

1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(T-Y-TP-H-E)

NCBI accession no.

NP_001789.2

UniProt accession no.

P24941

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pThr160)

Gene Information

human ... CDK2(1017)

General description

Cyclin-dependent kinase 2 (CDK2), a nucleus-cytoplasm trafficking protein, belongs to the cyclin-dependent kinase (CDK) family. The CDK2 gene is located on human chromosome 12q13.2.

Immunogen

Peptide sequence around phosphorylation site of threonine 160 (T-Y-T(p)-H-E), according to the protein CDK2.

Biochem/physiol Actions

Cyclin-dependent kinase 2 (CDK2) protein participates in the recombination and differentiation of the cell. It plays a major role in metabolism, apoptosis, senescence, and meiosis. CDK2 is involved in the development of embryos and the remodeling of chromatin. It also plays a key role in DNA damage and DNA damage response (DDR). CDK2 controls the progression of the cell cycle. Changes in the activity of CDK2 might have an impact on human carcinogenesis. Absence of CDK2 results in DNA damage and DDR activation.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

Involved in the control of the cell cycle. Interacts with cyclins A, B1, B3, D, or E. Activity of CDK2 is maximal during S phase and G2.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

Certificates of Analysis (COA)

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D J Demetrick et al.
Cytogenetics and cell genetics, 66(1), 72-74 (1994-01-01)
Cyclin dependent kinases (CDK's) are kinases that interact with cyclins and regulate cell division. Genomic clones encoding human CDK2, CDK4, and CDK5 were obtained and mapped to their respective chromosomal loci using fluorescence in situ hybridization on human lymphocyte metaphase
Qi Liu et al.
DNA repair, 85, 102702-102702 (2019-11-16)
CDK2 (cyclin-dependent kinase 2), a member of the CDK family, has been shown to play a role in many cellular activities including cell cycle progression, apoptosis and senescence. Recently, accumulating evidence indicates that CDK2 is involved in DNA damage and

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