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SAB4300094

Sigma-Aldrich

Anti-phospho-FOXO1 (pSer256) antibody produced in rabbit

affinity isolated antibody

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Synonym(s):
Anti-FKH1 antibody produced in rabbit, Anti-FKHR antibody produced in rabbit, Anti-FOXO1A antibody produced in rabbit, Anti-forkhead box O1 antibody produced in rabbit
MDL number:
MFCD03791549
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

78-82 kDa

species reactivity

rat, human, mouse

concentration

1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(A-A-SP-M-D)

NCBI accession no.

NP_002006.2

UniProt accession no.

Q12778

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer256)

Gene Information

human ... FOXO1(2308)

General description

FOXO1 (forkhead box O1) is encoded by the gene mapped to human chromosome 13q14. The encoded protein is a transcription factor and is a member of the Foxo subfamily.

Immunogen

Peptide sequence around phosphorylation site of serine 256 (A-A-S(p)-M-D), according to the protein FOXO1.

Application

Anti-phospho-FOXO1 (pSer256) antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

FOXO1 (forkhead box O1) blocks the differentiation of cell in fetal pancreatic progenitor cells. It controls the differentiation of adipocytes. FOXO1 is involved in the insulin regulation of glucose-6-phosphatase (G6p) expression. Additionally, this protein plays a vital role in tumor suppression by inducing growth arrest and apoptosis.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

Transcription factor.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Dense Pattern of Embryonal Rhabdomyosarcoma, a Lesion Easily Confused With Alveolar Rhabdomyosarcoma: A Report From the Soft Tissue Sarcoma Committee of the Children?s Oncology Group
Rudzinski ER
American Journal of Clinical Pathology, 140, 82-90 (2013)
The Forkhead Transcription Factor Foxo1 Regulates Adipocyte Differentiation
Nakae J
Developmental Cell, 4, 119-129 (2003)
The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic ? cell growth
Nakae J
The Journal of Clinical Investigation, 110, 1839?1847-1839?1847 (2002)
Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation
Huang H
Proceedings of the National Academy of Sciences of the USA, 102, 1649-1654 (2005)
Forkhead Protein FoxO1 Acts as a Repressor to Inhibit Cell Differentiation in Human Fetal Pancreatic Progenitor Cells.
Jiang Z
Journal of Diabetes Research (2017)
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