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Key Documents

Safety Information

SAB4300044

Sigma-Aldrich

Anti-phospho-PTEN (pSer380/pThr382/pThr383) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-10q23del antibody produced in rabbit, Anti-BZS antibody produced in rabbit, Anti-MGC11227 antibody produced in rabbit, Anti-MHAM antibody produced in rabbit, Anti-phosphatase and tensin homolog antibody produced in rabbit

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20 PKG
CN¥722.66

CN¥722.66

Estimated to ship onJune 30, 2025Details

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20 PKG
CN¥722.66

About This Item

MDL number:
MFCD02097285
UNSPSC Code:
12352203
NACRES:
NA.41

CN¥722.66

Estimated to ship onJune 30, 2025Details

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~54 kDa

species reactivity

human, rat, mouse

concentration

1 mg/mL

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Sucrose Molecular Biology Grade

573113

Sucrose

biological source

bakers yeast

biological source

-

biological source

Saccharomyces cerevisiae

biological source

-

form

solid

form

solid

form

lyophilized powder

form

solid

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

15-25°C

foreign activity

α-galactosidase (melibiase) ≤0.01%

foreign activity

α-galactosidase (melibiase), essentially free

foreign activity

-

foreign activity

DNases, proteases, RNases, none detected

Quality Level

300

Quality Level

200

Quality Level

200

Quality Level

200

Immunogen

Peptide sequence around phosphorylation site of threonine 380/382/383 (R-Y-S(p)-D-T(p)-T(p)-D-S), according to the protein PTEN.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

新产品

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    Certificates of Analysis (COA)

    Lot/Batch Number
    511711056

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    Prerna Malaney et al.
    Cell cycle (Georgetown, Tex.), 17(8), 947-962 (2017-11-08)
    PTEN phosphorylation at its C-terminal (C-tail) serine/threonine cluster negatively regulates its tumor suppressor function. However, the consequence of such inhibition and its downstream effects in driving lung cancer remain unexplored. Herein, we ascertain the molecular mechanisms by which phosphorylation compromises
    Kasra Khalaj et al.
    American journal of respiratory and critical care medicine, 206(4), 476-487 (2022-06-08)
    Rationale: Pulmonary hypoplasia secondary to congenital diaphragmatic hernia is characterized by reduced branching morphogenesis, which is responsible for poor clinical outcomes. Administration of amniotic fluid stem cell extracellular vesicles (AFSC-EVs) rescues branching morphogenesis in rodent fetal models of pulmonary hypoplasia.
    Lili Liu et al.
    Bioscience reports, 40(5) (2020-05-19)
    The present study aims to reveal the molecular mechanism of peroxisome proliferator-activated receptor γ (PPARγ) on sepsis-induced acute lung injury (ALI). To do that, the rat injury model was established using cecal ligation and perforation (CLP) method, followed by different

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