SAB4200761
Anti-Vimentin Antibody
mouse monoclonal, LN-6
Synonym(s):
Anti-VIM
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Pricing and availability is not currently available.
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Product Name
Anti-Vimentin antibody, Mouse monoclonal, clone LN-6, purified from hybridoma cell culture
biological source
mouse
Quality Level
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
LN-6, monoclonal
form
buffered aqueous solution
mol wt
~58 kDa
species reactivity
rat, human, porcine, monkey, bovine, canine, mouse, rabbit, hamster
enhanced validation
independent
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Related Categories
1 of 4
This Item | 194512 | 822277 | SAAR2235020 |
|---|---|---|---|
| assay ≥99.9% (GC) | assay - | assay ≥99.5% (GC) | assay - |
| Quality Level 100 | Quality Level - | Quality Level 200 | Quality Level - |
| form liquid | form liquid | form liquid | form liquid |
| autoignition temp. 801 °F | autoignition temp. 801 °F | autoignition temp. 801 °F | autoignition temp. 801 °F |
| vapor density 3 (20 °C, vs air) | vapor density 3 (20 °C, vs air) | vapor density 3 (20 °C, vs air) | vapor density 3 (20 °C, vs air) |
General description
Anti-Vimentin antibody, Mouse monoclonal (mouse IgM isotype) is derived from the LN-6 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from mouse. Vimentin protein is localized in a wide range of cell types, including pancreatic precursor cells, sertoli cells, mesangial cells, trophoblastic giant cells, neuronal precursor cells, fibroblasts, macrophages, endothelial cells of lung blood vessels, renal tubular cells, neutrophils, leukocytes and renal stromal cells.
Vimentin is a specific type III intermediate filament (IF) protein. It is abundantly expressed in mesenchymal cells. The gene encoding vimentin is located on human chromosome 10p13.
Specificity
Anti-Vimentin antibody, Mouse monoclonal specifically recognizes a unique epitope of Vimentin protein which is not expressed in cells of hematopoetic derivation. The antibody is reactive with benign and malignant tumors of mesenchymal and neural derivation but does not react with normal and malignanat human lymphoid cells or derived malignancies. The antibody reacts with Vimentin from human, hamster, mouse, rat, canine, monkey, bovine, porcine and rabbit origin.
Immunogen
Human thymic nuclear extract
Application
Anti-Vimentin antibody, Mouse monoclonal may be used in:
- immunoblotting
- immunofluorescence
- flow cytometry
- immunoprecipitation
- immunohistochemistry
Biochem/physiol Actions
Vimentin helps to preserve the structure of cells and stability of tissue in mesenchymal cells. It is involved in tumorigenesis, EMT (epithelial mesenchymal transition) and the metastatic of cancer. It also controls infectious internalization of human papillomavirus 16 pseudovirions.
Vimentin protein plays a significant role in supporting and anchoring the cellular position of organelles such as the nucleus, endoplasmic reticulum, mitochondria, maintenance of cell shape, the endurance of mechanical stress of mesenchymal cells and motility. Overexpression of the vimentin gene is observed in various epithelial cancers, including prostate, gastrointestinal tumors, central nervous system (CNS) tumors, breast, malignant melanoma and lung cancer.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
Storage and Stability
For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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The gene encoding human vimentin is located on the short arm of chromosome 10.
Ferrari S E R G I O, et al.
American Journal of Human Genetics, 41(4), 616-616 (1987)
Viscoelastic properties of vimentin compared with other filamentous biopolymer networks.
Janmey PA, et al.
The Journal of Cell Biology, 113(1), 155-160 (1991)
Vimentin modulates infectious internalisation of HPV16 pseudovirions.
Schafer G, et al.
Journal of Virology, 91(16), e00307-e00317 (2017)
Arun Satelli et al.
Cellular and molecular life sciences : CMLS, 68(18), 3033-3046 (2011-06-04)
Vimentin, a major constituent of the intermediate filament family of proteins, is ubiquitously expressed in normal mesenchymal cells and is known to maintain cellular integrity and provide resistance against stress. Vimentin is overexpressed in various epithelial cancers, including prostate cancer
Vimentin is a potential prognostic factor for tongue squamous cell carcinoma among five epithelial?mesenchymal transition-related proteins.
Liu P F, et al.
PLoS ONE, 12(6), e0178581-e0178581 (2017)
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