SAB3500929
Anti-RIFT VALLEY FEVER VIRUS antibody produced in rabbit
affinity isolated antibody
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UNSPSC Code:
12352203
NACRES:
NA.41
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
virus
concentration
1 mg/mL
technique(s)
ELISA: suitable
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
General description
Rift valley fever virus (RVFV) is an enveloped RNA virus belonging to the Phlebovirus genus of the family Bunyaviridae. RVFV possesses a single stranded segmented RNA genome composed of a large (L), a medium (M), and a small (S) segment. The L segment codes for the RNA-dependent RNA polymerase. The M segment codes for a polyprotein which is the precursor to the glycoproteins G1 and G2 and two non-structural proteins, 14K and 78K. The S segment codes for the nucleoprotein N and the non-structural protein NSs.
Immunogen
Antibody was raised against a 20 amino acid synthetic peptide near the center of the RVF virus.
Biochem/physiol Actions
Rift valley fever virus (RVFV) causes rift valley fever (RVF), an arthropod-borne viral disease. The virus is transmitted either by an arthropod or direct transmission by contact or aerosol among the hosts. The non-structural phosphoprotein (NSs) is responsible for the virulence in the pathogenic RVFV and suppresses human interferon gene expression. The fever is mainly observed in sheep and cattle. In humans, RVF clinical symptoms includes benign fever to severe encephalitis, retinitis, and fatal hepatitis with haemorrhagic fever. RVFV may block α/β interferon (IFN-α/β) expression in host and may target transcription factor aswell TFIIH.
Features and Benefits
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Linkage
The action of this antibody can be blocked using blocking peptide SBP3500929.
Physical form
Supplied at 1 mg/mL in PBS with 0.02% sodim azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Description
Pricing
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
Genetic evidence for an interferon-antagonistic function of rift valley fever virus non-structural protein NSs
Bouloy M, et al.
Journal of Virology, 75(3), 1371-1377 (2001)
Mutagen-directed attenuation of Rift Valley fever virus as a method for vaccine development
Caplen H, et al.
The Journal of General Virology, 66, 2271-2277 (1985)
NSs protein of Rift Valley fever virus blocks interferon production by inhibiting host gene transcription
Billecocq A, et al.
Journal of Virology, 78(18), 9798-9806 (2004)
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