Anti-FTO antibody produced in rabbit

FTO antibody was raised against a 15 amino acid peptide from near the amino terminus of human FTO.

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Rising obesity rates are rapidly becoming a growing health concern in the developing world. The fat mass and obesity associated gene (FTO) is the first gene discovered to contribute to common forms of human obesity. FTO is a member of the non-heme dioxygenase superfamily, encoding a 2-oxoglutarate-dependent nucleic acid demethylase whose mRNA is widely expressed, especially in neurons of feeding-related nuclei of the brain. FTO mRNA in the arcuate nucleus in mice is up-regulated by feeding and down-regulated during fasting, although the opposite pattern has been observed in rats. At least four isoforms of FTO are known to exist.

The action of this antibody can be blocked using blocking peptide SBP3500038.

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

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