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Merck
CN

SAB2900695

Anti-ADCYAP1R1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

ADCYAP1R1, PAC1, PAC1-R, PACAP receptor 1, Pac1 receptor, Pac1 receptors

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

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Product Name

Anti-ADCYAP1R1 antibody produced in rabbit, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

dog, human, Xenopus, chicken, monkey

technique(s)

immunohistochemistry: 15 μg/mL

UniProt accession no.

P41586

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... ADCYAP1R1(117)

Biochem/physiol Actions

Adenylate cyclase activating polypeptide 1 (pituitary) receptor type I (ADCYAP1R1) or pituitary adenylate cyclase 1 receptor (PAC1R) protein can activate the adenylyl cyclase stimulatory G protein Gs. It regulates circadian rhythm, food intake, and the immune system. PAC1R plays a vital role in glucose metabolism, learning and memory, neuronal ontogenesis, and apoptosis. ADCYAP1R1 is identified as a potential drug target for mental disorders and dry eye syndrome.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

Adenylate cyclase activating polypeptide 1 (pituitary) receptor type I (ADCYAP1R1) or pituitary adenylate cyclase 1 receptor (PAC1R) protein is a member of the class B G-protein-coupled receptors (GPCRs). It is expressed ubiquitously in the central nervous system (CNS) and peripheral tissues. It has an N-terminal extracellular domain (ECD) and a transmembrane domain (TMD). ADCYAP1R1 gene is located on human chromosome 7p14.

Immunogen

Synthetic 17 amino acid peptide from C-terminus of human ADCYAP1R1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Panda, Dog, Bat, Chicken, Lizard, Xenopus (100%); Stickleback, Pufferfish, Zebrafish (94%); Mouse, Rat, Hamster, Elephant, Bovine, Horse, Pig (88%).

Physical form

Solution in phosphate-buffered saline containing less than 0.1% sodium azide.
Supplied at 1 mg/ml

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
42697

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M Stoffel et al.
Genomics, 23(3), 697-699 (1994-10-01)
The gene encoding the human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R1) was mapped to chromosome 7 by PCR analysis of genomic DNA from a human/rodent somatic cell hybrid mapping panel. This assignment was confirmed and the gene
Kazuhiro Kobayashi et al.
Nature structural & molecular biology, 27(3), 274-280 (2020-03-12)
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic neuropeptide hormone. The PACAP receptor PAC1R, which belongs to the class B G-protein-coupled receptors (GPCRs), is a drug target for mental disorders and dry eye syndrome. Here, we present a cryo-EM structure

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